Aglaia silvestris
Aglaia silvestris
Aglaia silvestris, a plant with origins in Southeast Asia, has not been traditionally used for any specific medicinal purposes. Scientific studies have identified various triterpenes, including 3,4-secodammaranes and 20R/20S-configured derivatives, from different sources of the plant. Silvestrol and episilvestrol isolated from Aglaia silvestris demonstrated potent in vitro cytotoxic activity against several human cancer cell lines, suggesting potential anti-cancer properties. Additionally, two resveratrol oligomers were found to inhibit cathepsin L activity, which may potentially suppress SARS-CoV-2 entry, and three terpenes showed promise as inhibitors of the p53-MDM2 interaction. No major safety issues or drug interactions have been recorded for Aglaia silvestris, but further research is needed to confirm these findings and explore its potential applications comprehensively.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- The study identified various triterpenes, including 3,4-secodammaranes and 20R/20S isomers, in different provenances of Aglaia silvestris.
- Silvestrol and episilvestrol, isolated from Aglaia silvestris, showed potent in vitro cytotoxic activity against several human cancer cell lines.
- Two resveratrol oligomers inhibit cathepsin L activity, potentially suppressing SARS-CoV-2 entry.
- Three terpenes were identified as potential inhibitors of the p53-MDM2 interaction.
- The study updates on phytochemical and biological investigations of rocaglate derivatives from Aglaia species, highlighting their potential as lead compounds with antineoplastic and antiviral effects.
Frequently asked questions
What is Aglaia silvestris?
Aglaia silvestris (Aglaia silvestris) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Aglaia silvestris?
5 sourced findings are recorded for Aglaia silvestris; the strongest carries evidence grade D. For example: The study identified various triterpenes, including 3,4-secodammaranes and 20R/20S isomers, in different provenances of Aglaia silvestris.
How strong is the evidence for Aglaia silvestris?
The strongest finding for Aglaia silvestris carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Aglaia silvestris safe? What are the side effects?
No major safety issues are recorded for Aglaia silvestris in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Aglaia silvestris interact with medications?
No drug interactions are recorded for Aglaia silvestris in our sources. This does not rule them out — check with a pharmacist.
Is Aglaia silvestris a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Silvestrol and episilvestrol, potential anticancer rocaglate derivatives from Aglaia silvestris. literature abstract metadata
- T2 Silvaglins and related 2,3-secodammarane derivatives - unusual types of triterpenes from Aglaia silvestris. literature abstract metadata
- T2 Promising Terpenes as Natural Antagonists of Cancer: An In-Silico Approach. literature abstract metadata
- T2 Update on Phytochemical and Biological Studies on Rocaglate Derivatives from Aglaia Species. literature abstract metadata
- T2 Two Resveratrol Oligomers Inhibit Cathepsin L Activity to Suppress SARS-CoV-2 Entry. literature abstract metadata