Japanese Angelica Tree
Aralia elata
Aralia elata, also known as Hehuangpi or Duzhong, is a traditional Chinese medicinal plant. Its use in traditional medicine primarily focuses on treating conditions like rheumatism and lower back pain, though specific applications are not extensively documented. Scientific evidence indicates that extracts from Aralia elata have shown promise in various fields; for instance, leaf extracts were used to synthesize ZnO-based nanoclusters effective in wastewater treatment. Additionally, a compound called Calenduloside E (CE) demonstrated potent anti-atherosclerotic activity by inhibiting phosphoglycerate kinase 1 and showed protective effects against ox-LDL-induced injury in HUVECs cells. Furthermore, total glycosides from the plant exhibited potential in alleviating airway inflammation and mucus hypersecretion in asthmatic mice models. Safety concerns are minimal with no major issues recorded, and there have been no reported drug interactions to date.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- Aralia elata compound Calenduloside E (CE) shows potent anti-atherosclerotic activity by inhibiting phosphoglycerate kinase 1 (PGK1).
- A derivative (C5) of Aralia elata's Calenduloside E showed protective activity against ox-LDL-induced HUVECs injury by targeting HSP90β.
- Aralia elata leaf extracts were used to synthesize ZnO-based nanoclusters that efficiently removed organic dyes from wastewater.
- GA treatment in asthmatic mice showed reduced airway inflammation and mucus hypersecretion with altered cytokine levels and gene expression.
Frequently asked questions
What is Japanese Angelica Tree?
Japanese Angelica Tree (Aralia elata) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Japanese Angelica Tree?
4 sourced findings are recorded for Japanese Angelica Tree; the strongest carries evidence grade D. For example: Aralia elata compound Calenduloside E (CE) shows potent anti-atherosclerotic activity by inhibiting phosphoglycerate kinase 1 (PGK1).
How strong is the evidence for Japanese Angelica Tree?
The strongest finding for Japanese Angelica Tree carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Japanese Angelica Tree safe? What are the side effects?
No major safety issues are recorded for Japanese Angelica Tree in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Japanese Angelica Tree interact with medications?
No drug interactions are recorded for Japanese Angelica Tree in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Japanese Angelica Tree?
Japanese Angelica Tree is also known as: Аралия высокая, Angelique du Japon.
Is Japanese Angelica Tree a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Discovery of Calenduloside E (CE) and its derivatives as the glycolytic enzyme phosphoglycerate kinase 1 (PGK1) inhibitors for suppressing atherogenesis. literature abstract metadata
- T2 Discovery and Evaluation of Novel Calenduloside E Derivatives Targeting HSP90β in Ox-LDL-Induced HUVECs Injury. literature abstract metadata
- T2 Ameliorative effects of total glycosides from Aralia elata on airway inflammation and mucus hypersecretion in asthmatic mice. literature abstract metadata
- T2 Aralia elata leaf extracts synthesize ZnO-based nanoclusters and their dye removal applications. literature abstract metadata