Arctium lappa
Arctium lappa
Arctium lappa, commonly known as burdock, is a plant traditionally used in various herbal practices but lacks specific recorded traditional uses. Scientific evidence suggests potential benefits for renal health and fibrosis reduction through mechanisms involving the S100A8/A9/NOX/NF-κB signaling pathway. Additionally, studies indicate that defatted arctigenin from burdock seeds can be incorporated into food products without adverse effects on sensory quality or phenolic compounds. Arctium lappa also shows promise in alleviating osteoarthritis pain by suppressing chondrocyte pyroptosis via the POU2F1/GRB10 axis and exhibits potent antimicrobial activity against certain pathogens. No major safety issues or drug interactions have been recorded, but further research is needed to fully understand its potential applications and effects.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- Burdock seed flour, when defatted using supercritical CO2, can be incorporated into gingerbread cookies without significantly affecting sensory quality or major phenolic compound stability.
- The study found that arctigenin from Arctium lappa alleviates osteoarthritis pain by suppressing chondrocyte pyroptosis through the POU2F1/GRB10 axis.
- Arc inhibited cell proliferation across various breast cancer subtypes in vitro and significantly suppressed tumor growth in vivo with no overt toxicity.
- ATG improves renal function and reduces fibrosis by regulating TCA cycle and oxidative phosphorylation impairments via the S100A8/A9/NOX/NF-κB signaling pathway.
- ALEO showed potent in vitro antimicrobial activity against several WHO-priority pathogens.
Frequently asked questions
What is Arctium lappa?
Arctium lappa (Arctium lappa) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Arctium lappa?
5 sourced findings are recorded for Arctium lappa; the strongest carries evidence grade D. For example: Burdock seed flour, when defatted using supercritical CO2, can be incorporated into gingerbread cookies without significantly affecting sensory quality or major phenolic compound stability.
How strong is the evidence for Arctium lappa?
The strongest finding for Arctium lappa carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Arctium lappa safe? What are the side effects?
No major safety issues are recorded for Arctium lappa in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Arctium lappa interact with medications?
No drug interactions are recorded for Arctium lappa in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Arctium lappa?
Arctium lappa is also known as: Лопух большой, Bardane commune.
Is Arctium lappa a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Effects of Gingerbread Cookie Enrichment with Native and Supercritical CO2-Defatted Burdock Seeds. literature abstract metadata
- T2 In silico and in vitro assessment of antimicrobial activity of Arctium lappa L. leaf and flower essential oil against WHO priority pathogens. literature abstract metadata
- T2 Preliminary Study on the Mechanism of Arctigenin in Alleviating Osteoarthritis Pain by Suppressing Chondrocyte Pyroptosis: The Potential Role of the POU2F1/GRB10 Axis. literature abstract metadata
- T2 Elucidating the therapeutic efficacy and mechanisms of arctigenin in ameliorating renal fibrosis: a combined transcriptomic and proteomic study. literature abstract metadata
- T2 Arctigenin Suppresses Breast Cancer Growth In Vitro and In Vivo Through Subtype-Specific Multi-Targeting Activity. literature abstract metadata