Artocarpus lacucha
Artocarpus lacucha
Artocarpus lacucha, commonly known as Indian beech or jackfruit tree, is native to tropical regions in Asia and has a long history of traditional use. While specific traditional uses for this plant are not well-documented, its various parts have been explored for their potential medicinal properties across different cultures. Scientific studies indicate that Artocarpus lacucha exhibits significant biological activity. The leaves contain compounds with notable α-glucosidase inhibitory activity and potent acetylcholinesterase inhibition, suggesting possible applications in managing diabetes and Alzheimer's disease. Additionally, the hexane extract from its bark shows strong antibacterial properties through membrane-disrupting effects against tested bacteria. The ethyl acetate bark extract demonstrated no cytotoxicity in vitro and was non-toxic in acute and subacute toxicity studies in rats at a dose of 400 mg/kg/day. To date, there are no major safety concerns or recorded drug interactions associated with Artocarpus lacucha. However, due to the limited research, further investigation is warranted before drawing definitive conclusions about its therapeutic potential and safety profile.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- The study found that Artocarpus lacucha ethyl acetate bark extract showed no cytotoxicity in vitro and was generally non-toxic in acute and subacute toxicity studies, with a NOAEL of 400 mg/kg/day.
- Artocarpus lacucha showed high cytotoxicity with a CC50 of 63.96 μg/mL in HepG2 cells.
- Artocarpus lacucha showed significant α-glucosidase inhibitory activity with one compound, while another displayed potent acetylcholinesterase inhibition.
- The hexane extract from Artocarpus lacucha bark, specifically obtained through Soxhlet extraction (AL-SOX), showed potent antibacterial activity with membrane-disrupting effects against certain bacteria.
Frequently asked questions
What is Artocarpus lacucha?
Artocarpus lacucha (Artocarpus lacucha) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Artocarpus lacucha?
4 sourced findings are recorded for Artocarpus lacucha; the strongest carries evidence grade D. For example: The study found that Artocarpus lacucha ethyl acetate bark extract showed no cytotoxicity in vitro and was generally non-toxic in acute and subacute toxicity studies, with a NOAEL of 400 mg/kg/day.
How strong is the evidence for Artocarpus lacucha?
The strongest finding for Artocarpus lacucha carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Artocarpus lacucha safe? What are the side effects?
No major safety issues are recorded for Artocarpus lacucha in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Artocarpus lacucha interact with medications?
No drug interactions are recorded for Artocarpus lacucha in our sources. This does not rule them out — check with a pharmacist.
Is Artocarpus lacucha a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Toxicological evaluation of Artocarpus lacucha ethyl acetate extract: in vitro and in vivo assessment. literature abstract metadata
- T2 Identification of specialized metabolites from Artocarpus lacucha as potent α-glucosidase and acetylcholinesterase inhibitors: enzyme kinetic, in vitro and in silico study. literature abstract metadata
- T2 Ethnobotany, Cytotoxicity and Color Stability of Karen Natural Colorants. literature abstract metadata
- T2 Membrane-disrupting antibacterial activity of Artocarpus lacucha bark extract: a mechanistic study through experimental and computational approaches. literature abstract metadata