Chinabark
Cinchona calisaya
Cinchona calisaya is an evergreen tree native to the Andean region of South America. While traditional uses are not well-documented, studies have explored its potential applications and properties. Research has optimized subcritical water extraction methods for polyphenols from Cinchona calisaya, revealing higher phenolic content and enhanced antimicrobial activity compared to conventional techniques. Additionally, a study found that artemisinin-hydroxychloroquine treatment alleviated pulmonary fibrosis by inhibiting epithelial-mesenchymal transition via the PI3K/AKT/GSK3β signaling pathway. Another investigation demonstrated that aqueous extracts from Cinchona calisaya and Cinchona pubescens could synthesize silver nanoparticles with moderate biological activities, suggesting potential applications in nanotechnology. The nearly complete diploid genome assembly of Cinchona calisaya provides a valuable resource for further research. No significant safety concerns or drug interactions have been reported to date.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- The study presents a nearly complete diploid genome assembly of Cinchona calisaya, providing a robust foundation for further research.
- The study found that artemisinin-hydroxychloroquine treatment alleviated pulmonary fibrosis by inhibiting epithelial-mesenchymal transition via PI3K/AKT/GSK3β signaling.
- This study optimized subcritical water extraction conditions for polyphenols from Cinchona calisaya, showing higher phenolic content and antimicrobial activity compared to traditional methods.
- AgNPs synthesized using Cinchona calisaya and Cinchona pubescens extracts showed moderate antioxidant, antibacterial, antifungal activities, and larvicidal potency.
Frequently asked questions
What is Chinabark?
Chinabark (Cinchona calisaya) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Chinabark?
4 sourced findings are recorded for Chinabark; the strongest carries evidence grade D. For example: The study presents a nearly complete diploid genome assembly of Cinchona calisaya, providing a robust foundation for further research.
How strong is the evidence for Chinabark?
The strongest finding for Chinabark carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Chinabark safe? What are the side effects?
No major safety issues are recorded for Chinabark in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Chinabark interact with medications?
No drug interactions are recorded for Chinabark in our sources. This does not rule them out — check with a pharmacist.
Is Chinabark a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 A near-complete genome assembly of Cinchona calisaya. literature abstract metadata
- T2 Plant-based synthesis of silver nanoparticles using aqueous leaf extracts of Cinchona calisaya Wedd. and Cinchona pubescens Vahl: physicochemical characterisation and biological activities. literature abstract metadata
- T2 Artemisinin-hydroxychloroquine combination from traditional antimalarial medicine attenuates pulmonary fibrosis via PI3K/AKT/GSK3β-mediated inhibition of epithelial-mesenchymal transition. literature abstract metadata
- T2 Optimization of Subcritical Water Extraction Process for Polyphenols from Cinchona calisaya and Their Activity Analysis. literature abstract metadata