Possum grape
Cissus verticillata
Cissus verticillata, commonly known as "wild grape," is a plant traditionally used in various folk remedies but lacks specific documented traditional uses. Scientific research has shown that Cissus verticillata leaf extract may reduce the production of advanced glycation end-products (AGEs) and reactive oxygen species (ROS) in vitro, suggesting potential anti-aging benefits. Additionally, CvLTI, a trypsin inhibitor from the leaves, demonstrated antibacterial, hemolytic, and immunomodulatory effects. In animal studies, Cissus verticillata extract (CVE) improved memory deficits and increased brain-derived neurotrophic factor (BDNF) levels in mice fed a high-fat diet, indicating possible cognitive benefits. CVE also reduced oxidative and ischemic stress-induced neuronal damage by mitigating inflammation and MAPK phosphorylation in cells and gerbils. To date, no major safety concerns or reported drug interactions have been recorded for Cissus verticillata.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- Cissus verticillata leaf extract reduced the production of AGEs and ROS in vitro.
- CvLTI, a trypsin inhibitor from Cissus verticillata leaves, showed antibacterial, hemolytic, and immunomodulatory effects.
- CVE treatment improved memory deficits and increased BDNF levels in HFD-fed mice.
- CVE treatment reduced oxidative and ischemic stress-induced neuronal damage in cells and gerbils by mitigating inflammation and MAPK phosphorylation.
Frequently asked questions
What is Possum grape?
Possum grape (Cissus verticillata) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Possum grape?
4 sourced findings are recorded for Possum grape; the strongest carries evidence grade D. For example: Cissus verticillata leaf extract reduced the production of AGEs and ROS in vitro.
How strong is the evidence for Possum grape?
The strongest finding for Possum grape carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Possum grape safe? What are the side effects?
No major safety issues are recorded for Possum grape in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Possum grape interact with medications?
No drug interactions are recorded for Possum grape in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Possum grape?
Possum grape is also known as: Feuilles cotaire.
Is Possum grape a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Cissus verticillata Extract Decreases Neuronal Damage Induced by Oxidative Stress in HT22 Cells and Ischemia in Gerbils by Reducing the Inflammation and Phosphorylation of MAPKs. literature abstract metadata
- T2 Extracts from the Leaves of Cissus verticillata Ameliorate High-Fat Diet-Induced Memory Deficits in Mice. literature abstract metadata
- T2 A Novel Trypsin Inhibitor With Immunomodulatory Activity From the Leaves of Cissus verticillata subsp. verticillata (L.) Nicolson & C.E. Jarvis. literature abstract metadata
- T2 Cissus verticillata Leaf Extract Decreases the Production of AGEs and ROS In Vitro. literature abstract metadata