Possum grape
Cissus verticillata
Cissus verticillata, a traditional medicine plant, is primarily found in tropical regions of Africa. While it has not been traditionally used for specific medicinal purposes, studies have shown promising results. In vitro research indicates that Cissus verticillata leaf extract may reduce the production of AGEs and ROS, suggesting potential benefits against oxidative stress. Additionally, a trypsin inhibitor from its leaves, known as CvLTI, demonstrated antibacterial, hemolytic, and immunomodulatory effects. Further studies in mice indicated that CVE treatment improved memory deficits and increased BDNF levels in the hippocampus of high-fat diet-fed animals. In another study, CVE treatment reduced oxidative and ischemic stress-induced neuronal damage by mitigating inflammation and MAPK phosphorylation. Safety data for Cissus verticillata is currently limited but does not indicate any major issues. There are also no recorded drug interactions at this time.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- Cissus verticillata leaf extract reduced the production of AGEs and ROS in vitro.
- CvLTI, a trypsin inhibitor from Cissus verticillata leaves, showed antibacterial, hemolytic, and immunomodulatory effects.
- CVE treatment improved memory deficits and increased BDNF levels in HFD-fed mice.
- CVE treatment reduced oxidative and ischemic stress-induced neuronal damage in cells and gerbils by mitigating inflammation and MAPK phosphorylation.
Frequently asked questions
What is Possum grape?
Possum grape (Cissus verticillata) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Possum grape?
4 sourced findings are recorded for Possum grape; the strongest carries evidence grade D. For example: Cissus verticillata leaf extract reduced the production of AGEs and ROS in vitro.
How strong is the evidence for Possum grape?
The strongest finding for Possum grape carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Possum grape safe? What are the side effects?
No major safety issues are recorded for Possum grape in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Possum grape interact with medications?
No drug interactions are recorded for Possum grape in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Possum grape?
Possum grape is also known as: Feuilles cotaire.
Is Possum grape a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Cissus verticillata Extract Decreases Neuronal Damage Induced by Oxidative Stress in HT22 Cells and Ischemia in Gerbils by Reducing the Inflammation and Phosphorylation of MAPKs. literature abstract metadata
- T2 Extracts from the Leaves of Cissus verticillata Ameliorate High-Fat Diet-Induced Memory Deficits in Mice. literature abstract metadata
- T2 A Novel Trypsin Inhibitor With Immunomodulatory Activity From the Leaves of Cissus verticillata subsp. verticillata (L.) Nicolson & C.E. Jarvis. literature abstract metadata
- T2 Cissus verticillata Leaf Extract Decreases the Production of AGEs and ROS In Vitro. literature abstract metadata