Chinese goldthread
Coptis chinensis
Coptis chinensis, a traditional Chinese medicinal plant commonly known as Huanglian, is traditionally used in TCM for treating various ailments such as damp-heat conditions and inflammatory disorders. However, no specific traditional uses have been recorded for this particular species. Scientific evidence suggests that berberine, one of its active compounds, may inhibit gastric cancer liver metastasis by targeting CCL2, SPP1, and ALB; however, further experimental validation is necessary to confirm these findings. Additionally, a study identified 48 CcGRAS genes in Coptis chinensis showing tissue-specific co-expression with bZIP proteins under low-light conditions, potentially contributing to its therapeutic effects. The review also highlights the multifaceted pharmacological properties of curcumin and berberine, indicating their combined potential in various diseases through different mechanisms. No major safety issues or drug interactions have been recorded for Coptis chinensis thus far.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- A total of 48 CcGRAS genes were identified, showing differential expression under light stress compared to temperature stress, with specific co-expression patterns observed in underground tissues.
- This study suggests that berberine may inhibit gastric cancer liver metastasis by targeting CCL2, SPP1, and ALB, though further experimental validation is needed.
- TCM compounds including baicalin, berberine, curcumin, and icaritin may attenuate glycolysis and restore immune effector function in preclinical HCC.
- This review evaluates the multifaceted pharmacological properties and therapeutic potential of curcumin and berberine in various diseases, highlighting their combined effects.
Frequently asked questions
What is Chinese goldthread?
Chinese goldthread (Coptis chinensis) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Chinese goldthread?
4 sourced findings are recorded for Chinese goldthread; the strongest carries evidence grade D. For example: A total of 48 CcGRAS genes were identified, showing differential expression under light stress compared to temperature stress, with specific co-expression patterns observed in underground tissues.
How strong is the evidence for Chinese goldthread?
The strongest finding for Chinese goldthread carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Chinese goldthread safe? What are the side effects?
No major safety issues are recorded for Chinese goldthread in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Chinese goldthread interact with medications?
No drug interactions are recorded for Chinese goldthread in our sources. This does not rule them out — check with a pharmacist.
Is Chinese goldthread a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Emerging roles of combined curcumin and berberine in disease modulation: a comprehensive review of mechanisms and therapeutic relevance. literature abstract metadata
- T2 Traditional Chinese medicine reverses immune checkpoint resistance through lactate metabolic reprogramming in hepatocellular carcinoma: Mechanisms and therapeutic implications. literature abstract metadata
- T2 Genome-Wide Identification of the GRAS Transcription Factor Family in Coptis chinensis Reveals Tissue-Specific Co-Expression with bZIP Proteins Under Light Stress. literature abstract metadata
- T2 Exploring the Potential Molecular Mechanisms of Berberine against Gastric Cancer Liver Metastasis Based on Network Pharmacology and Bioinformatics. literature abstract metadata