Asiatic dogwood

Cornus officinalis, commonly known as the dogwood or shanzhuyu in traditional Chinese medicine, is a plant with a long history of use. Traditionally, it has been employed for various health concerns but specific recorded uses vary across different traditions and are not extensively documented. Scientific evidence suggests that Cornus officinalis contains compounds such as loganetin, cornuside, and COE (cornus extract), which have shown promising effects in several studies. Loganetin demonstrated dose-dependent degradation of CDK2 via KLHL6-mediated ubiquitination, promoting the differentiation of AML cells. COE exhibited neuroprotective properties by modulating oxidative stress, inhibiting apoptosis, and stabilizing dopaminergic/GABAergic neurotransmission in zebrafish models. Additionally, cornuside provided significant preventive protection against liver failure induced by LPS/D-GalN. The study also optimized ultrasound-assisted extraction using deep eutectic solvents to enhance polyphenol extraction from Cornus officinalis, highlighting its potential bioactivity. Safety and drug interactions for Cornus officinalis are currently not well-documented; no major safety issues or significant drug interactions have been reported in the available literature. However, further research is needed to fully understand its safety profile and potential interactions with other medications.

Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.