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Cynanchum paniculatum

Cynanchum paniculatum

Cynanchum paniculatum is a traditional medicine plant, though specific traditions using it are not well-documented. Scientific evidence suggests potential anti-inflammatory and antiproliferative properties; cynapanoside K has shown antiproliferative effects on HeLa cells by inducing apoptosis and S-phase cell cycle arrest. Geranyl acetone from the plant reduces inflammatory markers and paw swelling in rheumatoid arthritis rats without adverse effects, and both volatile (CP-VE) and aqueous (CP-AE) extracts exhibit anti-inflammatory activity in LPS-induced macrophage RAW 264.7 cells, although this effect is not entirely linked to paeonol content. The plant has been distinguished from Asarum heterotropoides using a multi-method approach involving E-nose, E-tongue, LC-HR-Q-TOF-MS/MS, and electrochemical fingerprint spectra. No major safety issues or drug interactions have been recorded for Cynanchum paniculatum.

At a glance
Best evidence
D
Cautions
—

Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.

What the science says

  • Cynapanoside K (4) showed antiproliferative effects on HeLa cells by inducing apoptosis and S-phase cell cycle arrest. D PMID
  • Cynanchum paniculatum's active compound geranyl acetone reduces inflammatory markers and improves histology in a rat model of rheumatoid arthritis without adverse effects. D PMID
  • The study found that both volatile (CP-VE) and aqueous (CP-AE) extracts of Cynanchum paniculatum showed anti-inflammatory effects in macrophage cells and zebrafish models, though the mechanisms may not fully correlate with paeonol content. D PMID
  • This study developed a multi-method approach using E-nose, E-tongue, LC-HR-Q-TOF-MS/MS, and electrochemical fingerprint spectra to distinguish Cynanchum paniculatum from Asarum heterotropoides. D PMID

Frequently asked questions

What is Cynanchum paniculatum?

Cynanchum paniculatum (Cynanchum paniculatum) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.

What does the scientific evidence say about Cynanchum paniculatum?

4 sourced findings are recorded for Cynanchum paniculatum; the strongest carries evidence grade D. For example: Cynapanoside K (4) showed antiproliferative effects on HeLa cells by inducing apoptosis and S-phase cell cycle arrest.

How strong is the evidence for Cynanchum paniculatum?

The strongest finding for Cynanchum paniculatum carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).

Is Cynanchum paniculatum safe? What are the side effects?

No major safety issues are recorded for Cynanchum paniculatum in our sources, but the data may be incomplete. Consult a qualified professional before use.

Does Cynanchum paniculatum interact with medications?

No drug interactions are recorded for Cynanchum paniculatum in our sources. This does not rule them out — check with a pharmacist.

Is Cynanchum paniculatum a proven treatment?

No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.

Sources

  1. T2 The anti-inflammatory effects of paeonol from Cynanchum paniculatum extracts on LPS-induced macrophage RAW 264.7 cells and Helicobacter pylori-infected gastrointestinal mucosal damaged zebrafish. literature abstract metadata
  2. T2 Exploring the mechanism of Cynanchum paniculatum (Bunge) Kitag's therapeutic strategy for rheumatoid arthritis: integrating network pharmacology, molecular docking and in vivo experiments. literature abstract metadata
  3. T2 Discrimination of poisonous and medicinal plants with similar appearance (Asarum heterotropoides vs. Cynanchum paniculatum) via a fusion method of E-nose, E-tongue, LC-HR-Q-TOF-MS/MS, and electrochemical fingerprint spectra. literature abstract metadata
  4. T2 C21 steroidal glycosides from Cynanchum paniculatum (Bunge) Kitagawa: structural elucidation and biological evaluation. literature abstract metadata

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