FolkKB

Chinese-quinine

Dichroa febrifuga

Dichroa febrifuga is a traditional Chinese medicinal plant. While its specific uses are not well-documented in traditional practices, it has shown promise in modern scientific research. Studies indicate that halofuginone, an inhibitor derived from Dichroa febrifuga, may reduce dura mater thickness and epidural fibrosis grades in rats, suggesting potential for treating certain neurological conditions. Additionally, halofuginone significantly inhibits colon cancer cell growth, while another compound, FFG, has been shown to restrict Porcine Epidemic Diarrhea Virus (PEDV) replication by modulating the IGF1R-driven PI3K/AKT-apoptosis axis. In a study involving Eimeria tenella-infected chicks, Dichroa febrifuga leaf extract (DFL) treatment improved growth performance, reduced oocyst shedding, and protected intestinal barrier integrity. Safety-wise, no major issues have been recorded, and there are currently no known drug interactions associated with Dichroa febrifuga or its derivatives.

At a glance
Best evidence
D
Cautions
—

Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.

What the science says

  • FFG restricts PEDV replication by modulating the PI3K/AKT-apoptosis pathway. D PMID
  • Halofuginone reduced dura mater thickness and epidural fibrosis grades in a rat craniectomy model. D PMID
  • Halofuginone, an inhibitor derived from Dichroa febrifuga, significantly inhibits colon cancer cell growth in synergy with bortezomib. D PMID
  • DFL treatment significantly improved growth performance, reduced oocyst shedding, and protected intestinal barrier integrity in E. tenella-infected chicks. D PMID

Frequently asked questions

What is Chinese-quinine?

Chinese-quinine (Dichroa febrifuga) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.

What does the scientific evidence say about Chinese-quinine?

4 sourced findings are recorded for Chinese-quinine; the strongest carries evidence grade D. For example: FFG restricts PEDV replication by modulating the PI3K/AKT-apoptosis pathway.

How strong is the evidence for Chinese-quinine?

The strongest finding for Chinese-quinine carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).

Is Chinese-quinine safe? What are the side effects?

No major safety issues are recorded for Chinese-quinine in our sources, but the data may be incomplete. Consult a qualified professional before use.

Does Chinese-quinine interact with medications?

No drug interactions are recorded for Chinese-quinine in our sources. This does not rule them out — check with a pharmacist.

Is Chinese-quinine a proven treatment?

No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.

Sources

  1. T2 The glutamyl-prolyl-tRNA synthetase 1 inhibitor halofuginone exerts synergistic antitumor effects with bortezomib in colon cancer cells. literature abstract metadata
  2. T2 Antifibrotic and anti-inflammatory properties of halofuginone in a rat craniectomy model. literature abstract metadata
  3. T2 Study on the therapeutic potential of Dichroa febrifuga Lour. as a novel natural anticoccidial agent for Eimeria tenella infection in chicks. literature abstract metadata
  4. T2 Febrifugine dihydrochloride restricts porcine epidemic diarrhea virus replication by modulating the IGF1R-driven PI3K/AKT-apoptosis axis. literature abstract metadata