Ash
Fraxinus
Fraxinus is a traditional medicine plant primarily associated with East Asian herbal practices. It has been traditionally used in various remedies but specific applications are not well-documented in historical or cultural records. Scientific evidence suggests that extracts from Fraxinus, particularly from species like Fraxinus mandshurica and Fraxinus chinensis, show promise in reducing inflammatory markers and improving redox balance, as indicated by a Caco-2/RAW264.7 co-culture model study. Additionally, research indicates that overexpression of certain genes in Fraxinus can enhance drought tolerance through lignin biosynthesis and activation of the phenylpropanoid pathway. The dioxygenase FcDOH2 from Fraxinus chinensis exhibits substrate-dependent bifunctionality, catalyzing O-demethylation and C8-hydroxylation of coumarins, which could have implications for plant breeding and biotechnology. No major safety concerns or drug interactions have been recorded for this plant.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- BFM from Fraxinus showed significant reduction in inflammatory markers and improvement in redox balance in a Caco-2/RAW264.7 co-culture model.
- Overexpression of Fraxinus mandshurica SPL2 enhances drought tolerance by promoting lignin biosynthesis and activating the phenylpropanoid pathway.
- A Fraxinus chinensis dioxygenase (FcDOH2) exhibits substrate-dependent bifunctionality, catalyzing O-demethylation and C8-hydroxylation of coumarins.
- The study developed prediction models for tree height and height to crown base of Fraxinus mandshurica, Juglans mandshurica, and Phellodendron amurense using TLS data, improving accuracy through the inclusion of multiple ecological factors.
- Fraxinus xanthoxyloides bark methanol extract showed potential anti-diabetic effects in alloxan-induced diabetic rats through multiple mechanisms.
- Mixed-species afforestation increased soil carbon and nitrogen storage more than monocultures, primarily due to higher proportions of larger aggregates.
Frequently asked questions
What is Ash?
Ash (Fraxinus) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Ash?
6 sourced findings are recorded for Ash; the strongest carries evidence grade D. For example: BFM from Fraxinus showed significant reduction in inflammatory markers and improvement in redox balance in a Caco-2/RAW264.7 co-culture model.
How strong is the evidence for Ash?
The strongest finding for Ash carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Ash safe? What are the side effects?
No major safety issues are recorded for Ash in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Ash interact with medications?
No drug interactions are recorded for Ash in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Ash?
Ash is also known as: ясень, frêne.
Is Ash a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Fraxinus mandshurica SPL2 enhances tolerance to drought stress by activating the phenylpropanoid pathway. literature abstract metadata
- T2 Anti-Inflammatory Activity of In Vitro Digested Manna in a Caco-2 and RAW264.7 Cells Co-Culture Model of Inflammatory Bowel Disease. literature abstract metadata
- T2 [Prediction models for tree height and height to crown base of individual trees in valuable hardwood broad-leaved forests of Northeast China based on terrestrial laser scanning data]. literature abstract metadata
- T2 Protective effects of Fraxinus xanthoxyloides bark in alloxan-induced diabetic rats: A phytochemical and pharmacological approach. literature abstract metadata
- T2 A Substrate-Dependent Bifunctional Dioxygenase from Fraxinus chinensis for O-Demethylation and C8-Hydroxylation of Coumarins. literature abstract metadata
- T2 Mixed-species afforestation stimulates the flow and turnover of carbon and nitrogen within soil aggregates in a degraded karst ecosystem. literature abstract metadata