Gentianella amarella
Gentianella amarella
Gentianella amarella, a plant traditionally used in East Asian herbal medicine, particularly in China and Japan, has not been extensively documented for specific traditional uses. Scientific research has isolated several compounds from this species, including two tetrahydroxanthones and six new tetrahydroxanthone glycosides from Gentianella amarella ssp. acuta, which showed weak to moderate inhibitory activities against AChE and MAO. Additionally, bellidifolin from the plant was found to reduce myocardial fibrosis by regulating TGF-β1/Smads, p38 signaling, and NR4A1 localization. Ten closely related xanthones were also isolated using high-speed countercurrent chromatography. No major safety issues or drug interactions have been recorded for Gentianella amarella, but further research is needed to fully understand its potential benefits and applications.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- Pollinator communities in grasslands recovering from military disturbance showed stronger associations with ancient grasslands than those recovering from intensive agriculture.
- Two tetrahydroxanthones and six new tetrahydroxanthone glycosides were isolated from Gentianella amarella ssp. acuta.
- Two new xanthone glycosides were isolated from Gentianella amarella ssp. acuta, and some compounds showed weak to moderate inhibitory activities against AChE and MAO.
- Bellidifolin from Gentianella amarella reduced myocardial fibrosis by regulating TGF-β1/Smads, p38 signaling, and NR4A1 localization.
- The study successfully isolated ten closely related xanthones from Gentianella amarella ssp. acuta using HSCCC.
Frequently asked questions
What is Gentianella amarella?
Gentianella amarella (Gentianella amarella) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Gentianella amarella?
5 sourced findings are recorded for Gentianella amarella; the strongest carries evidence grade D. For example: Pollinator communities in grasslands recovering from military disturbance showed stronger associations with ancient grasslands than those recovering from intensive agriculture.
How strong is the evidence for Gentianella amarella?
The strongest finding for Gentianella amarella carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Gentianella amarella safe? What are the side effects?
No major safety issues are recorded for Gentianella amarella in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Gentianella amarella interact with medications?
No drug interactions are recorded for Gentianella amarella in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Gentianella amarella?
Gentianella amarella is also known as: Горечавочка горьковатая, Gentiane amère.
Is Gentianella amarella a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Xanthones from Gentianella amarella ssp. acuta with acetylcholinesterase and monoamine oxidase inhibitory activities. literature abstract metadata
- T2 Preparative isolation of closely-related xanthones from Gentianella amarella ssp. acuta by High-speed countercurrent chromatography. literature abstract metadata
- T2 Tetrahydroxanthones from Mongolian medicinal plant Gentianella amarella ssp. acuta. literature abstract metadata
- T2 Bellidifolin Ameliorates Isoprenaline-Induced Myocardial Fibrosis by Regulating TGF-β1/Smads and p38 Signaling and Preventing NR4A1 Cytoplasmic Localization. literature abstract metadata
- T2 Species-habitat networks reveal conservation implications that other community analyses do not detect. literature abstract metadata