Chinese honey locust
Gleditsia sinensis
Gleditsia sinensis, also known as Chinese honey locust, is a traditional plant with origins in East Asia. While its use in traditional medicine has not been extensively documented, it has shown promise in modern scientific research. Studies have indicated significant trait variation among different Gleditsia hybrid combinations, particularly noting superior growth and photosynthetic characteristics. In terms of specific applications, extracts from the perisperm (Zaojiao Mi) of Gleditsia sinensis seeds demonstrated anti-ulcerative colitis effects by reducing inflammation and modulating the TLR4/NF-κB/NLRP3 pathway. Additionally, Gleditsia-derived mannan oligosaccharides (G-MOS) have been found to mitigate colitis symptoms more effectively than yeast-derived counterparts in immune regulation and gut microbiota modulation. Furthermore, Zaojiao Mi from the seeds of Gleditsia sinensis has shown potential in improving glycemic control and reducing cardiorenal injuries in type 2 diabetes mellitus (T2DM) rat models. No major safety issues or recorded drug interactions have been identified to date.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- Significant trait variation was observed among different Gleditsia hybrid combinations, with some showing superior growth and photosynthetic characteristics.
- Both yeast- and Gleditsia-derived MOSs mitigated colitis symptoms, but G-MOS was more effective in immune regulation and gut microbiota modulation.
- Gleditsia sinensis perisperm (Zaojiao Mi) showed anti-inflammatory effects in mice with DSS-induced colitis by regulating the TLR4/NF-κB/NLRP3 pathway and increasing SCFA levels.
- ZJMP from Gleditsia sinensis seeds significantly ameliorated type 2 diabetes and associated cardiorenal injuries in rats.
Frequently asked questions
What is Chinese honey locust?
Chinese honey locust (Gleditsia sinensis) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Chinese honey locust?
4 sourced findings are recorded for Chinese honey locust; the strongest carries evidence grade D. For example: Significant trait variation was observed among different Gleditsia hybrid combinations, with some showing superior growth and photosynthetic characteristics.
How strong is the evidence for Chinese honey locust?
The strongest finding for Chinese honey locust carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Chinese honey locust safe? What are the side effects?
No major safety issues are recorded for Chinese honey locust in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Chinese honey locust interact with medications?
No drug interactions are recorded for Chinese honey locust in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Chinese honey locust?
Chinese honey locust is also known as: Гледичия китайская.
Is Chinese honey locust a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Structure-dependent effects of yeast- and Gleditsia-derived mannan oligosaccharides on dextran sodium sulfate-induced colitis in mice. literature abstract metadata
- T2 Polysaccharide from Gleditsia sinensis Seed Endosperm Ameliorates Type 2 Diabetes and Its Associated Cardiorenal Injuries by Modulating TLR4/MyD88/NF-κB Pathway and Gut Microbiota. literature abstract metadata
- T2 Analysis of trait differences and identification of superior early growth combinations in interspecific hybrid progenies of Gleditsia sinensis. literature abstract metadata
- T2 Gleditsia sinensis perisperm ameliorates DSS-induced ulcerative colitis via the TLR4/NF-κB/NLRP3 signaling pathway: Safety evaluation and bioactive amino acid profiling. literature abstract metadata