Five-leaf gynostemma
Gynostemma pentaphyllum
Gynostemma pentaphyllum, a traditional Chinese herb, has been studied for its potential health benefits. Traditionally, there are no specific recorded uses of this plant in any tradition. Scientific evidence suggests that Gynostemma pentaphyllum may help manage blood sugar levels by reducing fasting plasma glucose, HbA1c, and 2-hour postprandial glucose levels. Additionally, studies indicate it might have potential for treating atherosclerosis through its effects on lipid profiles and foam cell formation in vitro. The extract also showed promise in protecting against oxidative stress and reducing hair graying. No significant safety concerns or major drug interactions have been reported to date.
- Best evidence
- A
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- This study identified 86 GpNAC genes in Gynostemma pentaphyllum and found that GpNAC68 enhances drought tolerance in transgenic Arabidopsis.
- Nar, from Gynostemma pentaphyllum, reduced foam cell formation in vitro and improved lipid profiles in HFD-induced ApoE-/- mice, suggesting potential for treating atherosclerosis.
- Gynostemma pentaphyllum significantly reduced fasting plasma glucose, HbA1c, and 2-hour postprandial glucose levels in patients.
- A time-delayed negative feedback loop involving GpGAB and GpGIB regulates ginsenoside biosynthesis in Gynostemma pentaphyllum after JA induction.
- Gynostemma pentaphyllum extract showed potential in protecting against H2O2-induced oxidative stress and reducing hair graying in mice.
Frequently asked questions
What is Five-leaf gynostemma?
Five-leaf gynostemma (Gynostemma pentaphyllum) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Five-leaf gynostemma?
5 sourced findings are recorded for Five-leaf gynostemma; the strongest carries evidence grade A. For example: This study identified 86 GpNAC genes in Gynostemma pentaphyllum and found that GpNAC68 enhances drought tolerance in transgenic Arabidopsis.
How strong is the evidence for Five-leaf gynostemma?
The strongest finding for Five-leaf gynostemma carries evidence grade A — strong evidence. Grades run A (strongest) to D (preliminary or traditional).
Is Five-leaf gynostemma safe? What are the side effects?
No major safety issues are recorded for Five-leaf gynostemma in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Five-leaf gynostemma interact with medications?
No drug interactions are recorded for Five-leaf gynostemma in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Five-leaf gynostemma?
Five-leaf gynostemma is also known as: Гиностемма пятилистная.
Is Five-leaf gynostemma a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Efficacy and mechanisms of Gynostemma pentaphyllum as a medicine food homology herb in glycemic control: a meta-analysis with review. literature abstract metadata
- T2 Narcissoside attenuates atherosclerosis by suppressing CD36-mediated foam cell formation via upregulation of NR4A1. literature abstract metadata
- T2 Comprehensive genome-wide mining and characterization of the NAC transcription factor family in Gynostemma pentaphyllum identifies GpNAC68 as a positive regulator of drought tolerance in transgenic Arabidopsis. literature abstract metadata
- T2 The Role of Gynostemma pentaphyllum Extract in Combating H2O2-Induced Oxidative Stress and Preventing Hair Graying. literature abstract metadata
- T2 Time-delayed activator-repressor regulation of ginsenoside biosynthesis in Gynostemma pentaphyllum. literature abstract metadata