Five-leaf gynostemma
Gynostemma pentaphyllum
Gynostemma pentaphyllum, also known as jiaogulan, is a traditional Chinese herb with roots in East Asian medicine. While its specific uses are not well-documented in traditional practices, studies have shown promising results for various health benefits. Scientific evidence suggests that GpNAC68 from this plant enhances drought tolerance in transgenic Arabidopsis and that nar, another compound found within the plant, may reduce foam cell formation and improve lipid profiles in mice with a high-fat diet-induced condition, potentially indicating therapeutic applications for atherosclerosis. Additionally, Gynostemma pentaphyllum has been observed to significantly lower fasting plasma glucose, HbA1c, and 2-hour postprandial glucose levels in patients, suggesting potential benefits for managing blood sugar levels. The time-delayed negative feedback loop involving GpGAB and GpGIB also indicates a complex regulatory mechanism governing ginsenoside biosynthesis following jasmonic acid induction. To date, no major safety concerns or recorded drug interactions have been identified with the use of Gynostemma pentaphyllum.
- Best evidence
- A
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- This study identified 86 GpNAC genes in Gynostemma pentaphyllum and found that GpNAC68 enhances drought tolerance in transgenic Arabidopsis.
- Nar, from Gynostemma pentaphyllum, reduced foam cell formation in vitro and improved lipid profiles in HFD-induced ApoE-/- mice, suggesting potential for treating atherosclerosis.
- Gynostemma pentaphyllum significantly reduced fasting plasma glucose, HbA1c, and 2-hour postprandial glucose levels in patients.
- A time-delayed negative feedback loop involving GpGAB and GpGIB regulates ginsenoside biosynthesis in Gynostemma pentaphyllum after JA induction.
- Gynostemma pentaphyllum extract showed potential in protecting against H2O2-induced oxidative stress and reducing hair graying in mice.
Frequently asked questions
What is Five-leaf gynostemma?
Five-leaf gynostemma (Gynostemma pentaphyllum) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Five-leaf gynostemma?
5 sourced findings are recorded for Five-leaf gynostemma; the strongest carries evidence grade A. For example: This study identified 86 GpNAC genes in Gynostemma pentaphyllum and found that GpNAC68 enhances drought tolerance in transgenic Arabidopsis.
How strong is the evidence for Five-leaf gynostemma?
The strongest finding for Five-leaf gynostemma carries evidence grade A — strong evidence. Grades run A (strongest) to D (preliminary or traditional).
Is Five-leaf gynostemma safe? What are the side effects?
No major safety issues are recorded for Five-leaf gynostemma in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Five-leaf gynostemma interact with medications?
No drug interactions are recorded for Five-leaf gynostemma in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Five-leaf gynostemma?
Five-leaf gynostemma is also known as: Гиностемма пятилистная.
Is Five-leaf gynostemma a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Efficacy and mechanisms of Gynostemma pentaphyllum as a medicine food homology herb in glycemic control: a meta-analysis with review. literature abstract metadata
- T2 Narcissoside attenuates atherosclerosis by suppressing CD36-mediated foam cell formation via upregulation of NR4A1. literature abstract metadata
- T2 Comprehensive genome-wide mining and characterization of the NAC transcription factor family in Gynostemma pentaphyllum identifies GpNAC68 as a positive regulator of drought tolerance in transgenic Arabidopsis. literature abstract metadata
- T2 The Role of Gynostemma pentaphyllum Extract in Combating H2O2-Induced Oxidative Stress and Preventing Hair Graying. literature abstract metadata
- T2 Time-delayed activator-repressor regulation of ginsenoside biosynthesis in Gynostemma pentaphyllum. literature abstract metadata