Helicia nilagirica
Helicia nilagirica
Helicia nilagirica is a plant traditionally not used for medicinal purposes. Its complete chloroplast genome has been characterized, revealing 132 genes and indicating close relation to Macadamia integrifolia. Scientific studies have shown that the active component helicid from this plant can improve depressive behaviors, learning, and cognitive functions in rats subjected to chronic stress by modulating SERTs and cAMP/PKA/CREB signaling pathways. Additionally, helicid exhibits potential as an analgesic and hypnotic, reducing mechanical allodynia and increasing non-rapid eye movement sleep in neuropathic pain-like model mice. Five compounds were isolated from the seeds of Helicia nilagirica, with three being previously unreported within the genus. No major safety issues or drug interactions have been recorded for this plant.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- Helicia nilagirica's active component helicid improved depressive behaviors, learning, and cognitive functions in rats subjected to chronic stress by modulating SERTs and cAMP/PKA/CREB signaling.
- Helicia nilagirica's active constituent helicid showed potential as an analgesic and hypnotic, reducing mechanical allodynia and increasing non-rapid eye movement sleep in neuropathic pain-like model mice.
- The complete chloroplast genome of Helicia nilagirica was characterized, containing 132 genes and showing close relation to Macadamia integrifolia.
- Five compounds were isolated from Helicia nilagirica seeds, with three previously unreported in the genus.
Frequently asked questions
What is Helicia nilagirica?
Helicia nilagirica (Helicia nilagirica) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Helicia nilagirica?
4 sourced findings are recorded for Helicia nilagirica; the strongest carries evidence grade D. For example: Helicia nilagirica's active component helicid improved depressive behaviors, learning, and cognitive functions in rats subjected to chronic stress by modulating SERTs and cAMP/PKA/CREB signaling.
How strong is the evidence for Helicia nilagirica?
The strongest finding for Helicia nilagirica carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Helicia nilagirica safe? What are the side effects?
No major safety issues are recorded for Helicia nilagirica in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Helicia nilagirica interact with medications?
No drug interactions are recorded for Helicia nilagirica in our sources. This does not rule them out — check with a pharmacist.
Is Helicia nilagirica a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 [Study on chemical constituents in seeds of Helicia nilagirica (II)]. literature abstract metadata
- T2 Helicid alleviates pain and sleep disturbances in a neuropathic pain-like model in mice. literature abstract metadata
- T2 Helicid Ameliorates Learning and Cognitive Ability and Activities cAMP/PKA/CREB Signaling in Chronic Unpredictable Mild Stress Rats. literature abstract metadata
- T2 Complete chloroplast genome of Helicia nilagirica Bedd. and its phylogenetic analysis. literature abstract metadata