Holarrhena floribunda
Holarrhena floribunda
Holarrhena floribunda, a plant native to tropical regions of Africa, has not been traditionally used in any known medical practices. Scientific research has identified seventeen steroidal alkaloids from its stem bark, with some showing moderate to good antiplasmodial activity, though the evidence is still limited and more studies are needed for confirmation. The 70% hydro-ethanol extract of Holarrhena floribunda stem bark demonstrated anti-anaphylactic and anti-oedematogenic effects in rats, comparable to standard drugs, and it also showed potential in trapping finer particles (PM2.5) compared to coarser ones (PM10). Additionally, the 70% hydro-ethanol extract was effective in suppressing arthritis both prophylactically and therapeutically at doses of 50-500 mg/kg. No major safety issues or drug interactions have been recorded for Holarrhena floribunda; however, further research is necessary to fully understand its potential benefits and risks.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- Seventeen steroidal alkaloids were identified from Holarrhena floribunda stem bark, with some showing moderate antiplasmodial activity.
- Holarrhena floribunda was found to be more efficient in trapping finer particles (PM2.5) compared to coarser particles (PM10).
- The 70% hydro-ethanol extract of Holarrhena floribunda stem bark showed anti-anaphylactic and anti-oedematogenic effects, comparable to standard drugs.
- HFE at 50-500 mg/kg dose-dependently suppressed Complete Freund's Adjuvant-induced arthritis in Sprague-Dawley rats.
Frequently asked questions
What is Holarrhena floribunda?
Holarrhena floribunda (Holarrhena floribunda) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Holarrhena floribunda?
4 sourced findings are recorded for Holarrhena floribunda; the strongest carries evidence grade D. For example: Seventeen steroidal alkaloids were identified from Holarrhena floribunda stem bark, with some showing moderate antiplasmodial activity.
How strong is the evidence for Holarrhena floribunda?
The strongest finding for Holarrhena floribunda carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Holarrhena floribunda safe? What are the side effects?
No major safety issues are recorded for Holarrhena floribunda in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Holarrhena floribunda interact with medications?
No drug interactions are recorded for Holarrhena floribunda in our sources. This does not rule them out — check with a pharmacist.
Is Holarrhena floribunda a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Prophylactic or therapeutic administration of Holarrhena floribunda hydro ethanol extract suppresses complete Freund's adjuvant-induced arthritis in Sprague-Dawley rats. literature abstract metadata
- T2 Hydro-ethanol extract of Holarrhena floribunda stem bark exhibits anti-anaphylactic and anti-oedematogenic effects in murine models of acute inflammation. literature abstract metadata
- T2 Particle and heavy metal accumulation by two plant species in a coal mining area of Odisha, India. literature abstract metadata
- T2 UHPLC-QTOF-ESI-MS/MS, SNAP-MS Identification, In Silico Prediction of Pharmacokinetic Properties of Constituents from the Stem Bark of Holarrhena floribunda (G. Don) T. Durand and Schinz (Apocynaceae). literature abstract metadata