Hop
Humulus
Humulus, commonly known as hops, is a plant traditionally associated with brewing beer. While its use in traditional medicine has not been extensively documented, it has shown potential benefits in various studies. Scientific evidence suggests that xanthohumol, a compound found in Humulus lupulus, may help improve symptoms of Crohn's disease by reducing secondary bile acids and increasing IL-10 levels. Additionally, Humulus extracts have demonstrated protective effects against kidney damage in animal models, potentially due to their antioxidant properties. Humulus scandens has shown promise in inhibiting non-small cell lung cancer growth and metastasis through the suppression of the PI3K/Akt pathway. However, there is currently no recorded evidence of significant safety issues or drug interactions related to this plant.
- Best evidence
- B
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- Humulus lupulus extract significantly reduced serum urea, creatinine, uric acid levels and renal MDA while increasing TAC, CAT, SOD, and GPx activities in CCl₄-induced nephrotoxicity rats.
- The study found variable interaction patterns between hop isolates against bacteria and chicken cells, with some additive and synergistic effects observed.
- Humulus scandens inhibited non-small cell lung cancer growth and metastasis by suppressing the PI3K/Akt pathway.
- Hops showed variable effects as feed additives in different animal species, with some benefits but also dose-dependent adverse impacts.
- Xanthohumol supplementation was associated with reduced secondary bile acids and increased IL-10, potentially improving symptoms in Crohn's disease patients.
- GWAS did not identify significant SNPs but found several candidate loci, including a wall-associated kinase, for Verticillium wilt resistance in hop.
Frequently asked questions
What is Hop?
Hop (Humulus) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Hop?
6 sourced findings are recorded for Hop; the strongest carries evidence grade B. For example: Humulus lupulus extract significantly reduced serum urea, creatinine, uric acid levels and renal MDA while increasing TAC, CAT, SOD, and GPx activities in CCl₄-induced nephrotoxicity rats.
How strong is the evidence for Hop?
The strongest finding for Hop carries evidence grade B — moderate evidence. Grades run A (strongest) to D (preliminary or traditional).
Is Hop safe? What are the side effects?
No major safety issues are recorded for Hop in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Hop interact with medications?
No drug interactions are recorded for Hop in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Hop?
Hop is also known as: Хмель, Houblon.
Is Hop a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Modulation of Microbiota-Derived Bile Acids Linked to Symptom Amelioration in Crohn's Disease: Insights From a Randomized Clinical Trial With Xanthohumol Supplementation. literature abstract metadata
- T2 The potential of Humulus scandens in delaying non-small cell lung cancer: Targeting the PI3K/Akt signaling pathway to inhibit tumor growth and metastasis. literature abstract metadata
- T2 Mixture dependent correlation patterns in antibacterial and cytotoxic activities of five hop isolates. literature abstract metadata
- T2 Protective Effects of Humulus lupulus L. Extract on CCl₄-Induced Nephrotoxicity in Rats. literature abstract metadata
- T2 Association-Based Analysis of Verticillium Wilt Resistance in a Bi-Parental Hop (Humulus lupulus L.) Population for Marker Development in Breeding. literature abstract metadata
- T2 Humulus lupulus L. in Animal Nutrition: Phytochemical Profile, Bioactive Properties, and Applications as a Functional Feed Additive-A Comprehensive Review. literature abstract metadata