Bangahpul (East Asian soup-mint)
Isodon japonicus
Isodon japonicus, a plant traditionally used in some East Asian herbal practices but with no specific traditional uses documented, has shown potential therapeutic effects primarily through its active compound glaucocalyxin A. Scientific evidence suggests that this compound may suppress the proliferation of non-small cell lung cancer (NSCLC) cells by inhibiting the SRC/PI3K/AKT signaling pathway and inducing apoptosis. Additionally, network pharmacology studies indicate that glaucocalyxin A might also be effective in mitigating periodontitis and reducing inflammation in ulcerative colitis mice through its impact on key pathways such as α-linolenic acid metabolism, PTGS2, PLA2G15, EGFR, MMP9, and the PI3K/AKT/mTOR signaling pathway. While no major safety issues or drug interactions have been recorded, further research is necessary to fully understand its efficacy and potential applications.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- This study found that glaucocalyxin A reduces inflammation in ulcerative colitis mice by inhibiting PI3K/AKT/mTOR signaling.
- RB suppresses NSCLC proliferation and induces apoptosis by inhibiting the SRC/PI3K/AKT signaling pathway.
- The study identified α-linolenic acid metabolism as a key pathway through which glaucocalyxin A may exert therapeutic effects on non-small cell lung cancer, targeting PTGS2, PLA2G15, and EGFR.
- Network pharmacology and biological experiments suggested that Glaucocalyxin A from Isodon japonicus may inhibit MMP9 and suppress pro-inflammatory cytokine secretion, potentially mitigating periodontitis.
Frequently asked questions
What is Bangahpul (East Asian soup-mint)?
Bangahpul (East Asian soup-mint) (Isodon japonicus) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Bangahpul (East Asian soup-mint)?
4 sourced findings are recorded for Bangahpul (East Asian soup-mint); the strongest carries evidence grade D. For example: This study found that glaucocalyxin A reduces inflammation in ulcerative colitis mice by inhibiting PI3K/AKT/mTOR signaling.
How strong is the evidence for Bangahpul (East Asian soup-mint)?
The strongest finding for Bangahpul (East Asian soup-mint) carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Bangahpul (East Asian soup-mint) safe? What are the side effects?
No major safety issues are recorded for Bangahpul (East Asian soup-mint) in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Bangahpul (East Asian soup-mint) interact with medications?
No drug interactions are recorded for Bangahpul (East Asian soup-mint) in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Bangahpul (East Asian soup-mint)?
Bangahpul (East Asian soup-mint) is also known as: Прутьевик японский.
Is Bangahpul (East Asian soup-mint) a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Glaucocalyxin A alleviates ulcerative colitis by inhibiting PI3K/AKT/mTOR signaling. literature abstract metadata
- T2 Investigating the therapeutic mechanism of glaucocalyxin A in non-small cell lung cancer through integrated network pharmacology, metabolomics, molecular docking, and molecular dynamics simulations. literature abstract metadata
- T2 Network pharmacology analysis and biological validation of molecular targets regulated by glaucocalyxin a in periodontitis. literature abstract metadata
- T2 Rabdosin B suppresses proliferation of nonsmall cell lung cancer by regulating the SRC/PI3K/AKT signaling pathway. literature abstract metadata