Red-fruit Spicebush
Lindera erythrocarpa
Lindera erythrocarpa, a plant native to East Asia, has garnered attention for its potential medicinal properties. Traditionally, there are no documented uses of this plant in any known medical practices. Scientific research indicates that extracts from Lindera erythrocarpa exhibit several biological activities; for instance, methanol (ML) extracts reduce airway inflammation by inhibiting TAK1 activity in human bronchial epithelial cells. Additionally, unique nine oligomeric flavonoids found in the roots inhibit autophagy by blocking its fusion process in cells. The leaf ethanolic extract demonstrates vasodilatory effects in rats through the nitric oxide/cGMP pathway and channel modulation. Furthermore, dihydropashanone isolated from Lindera erythrocarpa shows protective effects against neuroinflammation and oxidative stress in cell models. To date, no significant safety concerns or drug interactions have been reported for this plant.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- Dihydropashanone isolated from Lindera erythrocarpa protected mouse hippocampus HT22 cells from glutamate-induced cell death.
- ML reduces airway inflammation by inhibiting TAK1 activity in human bronchial epithelial cells.
- Unique nine oligomeric flavonoids from Lindera erythrocarpa roots inhibit autophagy by blocking its fusion process in cells.
- Lindera erythrocarpa leaf ethanolic extract showed a significant reduction in blood pressure in spontaneously hypertensive rats.
Frequently asked questions
What is Red-fruit Spicebush?
Red-fruit Spicebush (Lindera erythrocarpa) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Red-fruit Spicebush?
4 sourced findings are recorded for Red-fruit Spicebush; the strongest carries evidence grade D. For example: Dihydropashanone isolated from Lindera erythrocarpa protected mouse hippocampus HT22 cells from glutamate-induced cell death.
How strong is the evidence for Red-fruit Spicebush?
The strongest finding for Red-fruit Spicebush carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Red-fruit Spicebush safe? What are the side effects?
No major safety issues are recorded for Red-fruit Spicebush in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Red-fruit Spicebush interact with medications?
No drug interactions are recorded for Red-fruit Spicebush in our sources. This does not rule them out — check with a pharmacist.
Is Red-fruit Spicebush a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Linderanidins A-F: Rare oligomeric flavonoids with an unusual C-3-C-4 linkage from the roots of Lindera erythrocarpa and their inhibitory activities on autophagy. literature abstract metadata
- T2 Methyl lucidone inhibits airway inflammatory response by reducing TAK1 activity in human bronchial epithelial NCI-H292 cells. literature abstract metadata
- T2 Dihydropashanone Isolated from Lindera erythrocarpa, a Potential Natural Product for the Treatment of Neurodegenerative Diseases. literature abstract metadata
- T2 Antihypertensive Effects of Lindera erythrocarpa Makino via NO/cGMP Pathway and Ca2+ and K+ Channels. literature abstract metadata