Panax notoginseng
Panax notoginseng
Panax notoginseng, commonly known as Sanqi, originates from traditional Chinese medicine practices. It is traditionally used to treat various conditions such as injuries, hemorrhages, and cardiovascular issues, but specific uses vary among different traditions. Scientific evidence suggests that saponins in Panax notoginseng may help reduce symptoms of colitis by altering the gut microbiota composition and modulating lipid metabolism. In diabetic nephropathy models, it has shown promise in improving kidney function and modulating inflammatory, oxidative stress, glucose, lipid, and fibrosis markers. However, the evidence is still limited and more research is needed to confirm these findings. No major safety concerns or drug interactions have been reported for Panax notoginseng; however, its totivirus content, particularly Actinidia totivirus 1 (AcToV1), which is closely related to Panax notoginseng virus A, should be considered in future studies and applications.
- Best evidence
- A
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- The study found a significant reduction in Panax notoginseng saponin metabolites, particularly deglycosylated products, in rats with colitis.
- G-Rh2 improved coronary heart disease in rats by modulating lipid metabolism, gut microbiota, and PI3K/AKT signaling.
- Panax notoginseng significantly improved kidney function and modulated inflammatory, oxidative stress, glucose, lipid, and fibrosis markers in diabetic nephropathy animal models.
- The study found that Qishen Yiqi Dripping Pills alleviate myocardial ischemia-reperfusion-induced fibrotic injury by targeting the TGF-β/Periostin axis.
- The study identified PnMYB38 as a key transcription factor regulating methyl jasmonate-induced saponin biosynthesis in Panax notoginseng.
- A novel totivirus, Actinidia totivirus 1 (AcToV1), was identified in kiwifruit plants and shares similarities with Panax notoginseng virus A.
Frequently asked questions
What is Panax notoginseng?
Panax notoginseng (Panax notoginseng) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Panax notoginseng?
6 sourced findings are recorded for Panax notoginseng; the strongest carries evidence grade A. For example: The study found a significant reduction in Panax notoginseng saponin metabolites, particularly deglycosylated products, in rats with colitis.
How strong is the evidence for Panax notoginseng?
The strongest finding for Panax notoginseng carries evidence grade A — strong evidence. Grades run A (strongest) to D (preliminary or traditional).
Is Panax notoginseng safe? What are the side effects?
No major safety issues are recorded for Panax notoginseng in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Panax notoginseng interact with medications?
No drug interactions are recorded for Panax notoginseng in our sources. This does not rule them out — check with a pharmacist.
Is Panax notoginseng a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 The effects of Panax notoginseng for the treatment of diabetic nephropathy in animals: a systematic review and meta-analysis. literature abstract metadata
- T2 The transcription factor PnMYB38 orchestrates methyl jasmonate-induced saponin biosynthesis in Panax notoginseng. literature abstract metadata
- T2 Qishen Yiqi Dripping Pills Alleviate Myocardial Ischemia-Reperfusion-Induced Fibrotic Injury by Inhibiting Fibroblast Activation via the Transforming Growth Factor-Beta/Periostin Pathway. literature abstract metadata
- T2 Genomic characterization of Actinidia totivirus 1 (AcToV1), a novel member of the genus Totivirus infecting kiwifruit. literature abstract metadata
- T2 Ginsenoside Rh2 Regulates PI3K/AKT Signaling, Metabolic Pathways, and the Gut Microbiota for Coronary Heart Disease Therapy. literature abstract metadata
- T2 Metabolic Profiling of Panax notoginseng Saponins in Rat Feces Under Colitis by UHPLC-QTOF-MS/MS. literature abstract metadata