Perilla frutescens var. crispa
Perilla frutescens var. crispa
Perilla frutescens var. crispa, a traditional plant used in East Asian medicine, particularly in Korean and Chinese herbal practices, has not been widely documented for specific traditional uses. Scientific evidence is limited but shows promise; a new compound from its leaves demonstrated inhibitory activity on nitric oxide production in cells. In clinical trials, herbal medicine derived from this plant was more effective than conventional treatments in improving total clinical efficacy and some secondary outcomes for patients with non-erosive reflux disease (NERD), though the quality of evidence is moderate to low. Rosmarinic acid found in Perilla frutescens var. crispa showed potential in alleviating symptoms of cystitis by reducing inflammation and prostaglandin E2 release in rats. The plant's activity against amyloid-β aggregation varies with cultivation factors such as flowering stage and nitrogen fertilization, indicating that these conditions may influence its effectiveness. No major safety issues or drug interactions have been recorded for this plant to date.
- Best evidence
- A
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- Rosmarinic acid partially alleviated HCl-induced cystitis in rats by reducing inflammation and prostaglandin E2 release.
- The activity of Perilla frutescens var. crispa against amyloid-β aggregation varied with cultivation factors like flowering stage and nitrogen fertilization.
- Herbal medicine was significantly more effective than conventional medical therapy in improving total clinical efficacy and some secondary outcomes in patients with NERD, but the quality of evidence was moderate to low.
- A new compound, 9-hydroxy-isoegomaketone, was identified from the leaves of a radiation mutant Perilla frutescens var. crispa cultivar and showed inhibitory activity on NO production in cells.
Frequently asked questions
What is Perilla frutescens var. crispa?
Perilla frutescens var. crispa (Perilla frutescens var. crispa) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Perilla frutescens var. crispa?
4 sourced findings are recorded for Perilla frutescens var. crispa; the strongest carries evidence grade A. For example: Rosmarinic acid partially alleviated HCl-induced cystitis in rats by reducing inflammation and prostaglandin E2 release.
How strong is the evidence for Perilla frutescens var. crispa?
The strongest finding for Perilla frutescens var. crispa carries evidence grade A — strong evidence. Grades run A (strongest) to D (preliminary or traditional).
Is Perilla frutescens var. crispa safe? What are the side effects?
No major safety issues are recorded for Perilla frutescens var. crispa in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Perilla frutescens var. crispa interact with medications?
No drug interactions are recorded for Perilla frutescens var. crispa in our sources. This does not rule them out — check with a pharmacist.
Is Perilla frutescens var. crispa a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 A New Monoterpene from the Leaves of a Radiation Mutant Cultivar of Perilla frutescens var. crispa with Inhibitory Activity on LPS-Induced NO Production. literature abstract metadata
- T2 Cultivation Factors That Affect Amyloid-β Aggregation Inhibitory Activity in Perilla frutescens var. crispa. literature abstract metadata
- T2 Rosmarinic acid ameliorates HCl-induced cystitis in rats. literature abstract metadata
- T2 Herbal medicine for the treatment of non-erosive reflux disease: A systematic review and meta-analysis. literature abstract metadata