Grecian Silkvine
Periploca graeca
Periploca graeca is a traditional medicine plant with origins in Asia Minor and the Mediterranean. Its use in folk medicine has not been extensively documented, though it has historical significance. Scientific studies have shown that periplocymarin from Periploca graeca does not interact significantly with P-glycoprotein or major cytochrome P450 enzymes, indicating potential for safe drug interactions. Cardenolides identified in the plant exhibit pro-apoptotic and cytostatic effects against leukemia and prostate cancer cells, suggesting possible therapeutic applications. Five of nine cardenolides tested demonstrated strong antiproliferative activity against PC-3 cells, while six new pregnane glycosides, including sulfated derivatives, were also discovered. To date, no major safety concerns or drug interactions have been reported for Periploca graeca.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- Periplocymarin is highly permeable and does not interact with P-glycoprotein or major cytochrome P450 enzymes.
- Periploca graeca cardenolides showed pro-apoptotic and cytostatic effects in leukemia and prostate cancer cells, with varying mechanisms.
- Five out of nine identified cardenolides from Periploca graeca showed strong antiproliferative effects against PC-3 cells.
- Six new pregnane glycosides, including sulfated derivatives, were identified from Periploca graeca.
Frequently asked questions
What is Grecian Silkvine?
Grecian Silkvine (Periploca graeca) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Grecian Silkvine?
4 sourced findings are recorded for Grecian Silkvine; the strongest carries evidence grade D. For example: Periplocymarin is highly permeable and does not interact with P-glycoprotein or major cytochrome P450 enzymes.
How strong is the evidence for Grecian Silkvine?
The strongest finding for Grecian Silkvine carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Grecian Silkvine safe? What are the side effects?
No major safety issues are recorded for Grecian Silkvine in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Grecian Silkvine interact with medications?
No drug interactions are recorded for Grecian Silkvine in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Grecian Silkvine?
Grecian Silkvine is also known as: Обвойник греческий, Bourreau-des-arbres.
Is Grecian Silkvine a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Sulfated pregnane glycosides from Periploca graeca. literature abstract metadata
- T2 Antiproliferative cardenolides from Periploca graeca. literature abstract metadata
- T2 Pro-apoptotic and cytostatic activity of naturally occurring cardenolides. literature abstract metadata
- T2 Periplocymarin is a potential natural compound for drug development: highly permeable with absence of P-glycoprotein efflux and cytochrome P450 inhibitions. literature abstract metadata