black pepper
Piper nigrum
Piper nigrum, commonly known as black pepper, originates from traditional medicine practices in India and Southeast Asia. Traditionally, it has been used for culinary purposes rather than medicinal ones, with specific therapeutic applications not well-documented. Scientific evidence suggests that nano-cocrystals of piperine-succinic acid may reduce serum cholesterol and triglyceride levels in rats, indicating potential cardiovascular benefits. Additionally, studies have shown that certain bacteria isolated from Piper nigrum can control Phytophthora capsici, a pathogen affecting black pepper plants, potentially enhancing plant growth and defense mechanisms. Research also indicates that structurally modified piperine derivatives may exhibit enhanced anticancer properties, though these findings are preliminary and require further investigation. No major safety concerns or known drug interactions have been recorded for Piper nigrum; however, the limited data precludes definitive conclusions on its broader applications.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- Nano-cocrystals of piperine-succinic acid significantly reduced serum cholesterol and triglyceride levels in male Wistar rats compared to intact piperine.
- The study identified Streptomyces minutiscleroticus and S. longisporoflavus with potential to control Phytophthora capsici and promote black pepper growth.
- Recent studies suggest that structurally modified piperine derivatives from Piper nigrum exhibit enhanced potential as anticancer agents.
- Piperine modulates DNA methylation, histone acetylation, and microRNA networks, showing potential as an epigenetic modulator in cancer and chronic diseases.
- The study found that pathogen infection by Phytophthora capsici induces changes in m⁶A modification in black pepper, potentially linking to defense responses.
Frequently asked questions
What is black pepper?
black pepper (Piper nigrum) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about black pepper?
5 sourced findings are recorded for black pepper; the strongest carries evidence grade D. For example: Nano-cocrystals of piperine-succinic acid significantly reduced serum cholesterol and triglyceride levels in male Wistar rats compared to intact piperine.
How strong is the evidence for black pepper?
The strongest finding for black pepper carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is black pepper safe? What are the side effects?
No major safety issues are recorded for black pepper in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does black pepper interact with medications?
No drug interactions are recorded for black pepper in our sources. This does not rule them out — check with a pharmacist.
What are the common names of black pepper?
black pepper is also known as: черный перец, poivre.
Is black pepper a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Unleashing the biocontrol and plant growth promoting potential of native rhizosphere Streptomyces spp. against Phytophthora foot rot in black pepper (Piper nigrum L.). literature abstract metadata
- T2 Pathogen-triggered m⁶A epitranscriptomic reprogramming is linked to host defense responses in the Piper nigrum-Phytophthora capsici pathosystem. literature abstract metadata
- T2 Recent advances in piperine and its derivatives as potential anticancer agents. literature abstract metadata
- T2 Nano-cocrystals of piperine-succinic acid and its antihyperlipidemic effect in male Wistar rats. literature abstract metadata
- T2 Piperine as a Multifunctional Epigenetic Modulator: Integrative Molecular Insights into Cancer and Chronic Disease Therapy. literature abstract metadata