Pogostemon cablin
Pogostemon cablin
Pogostemon cablin, commonly known as patchouli, is a plant traditionally used in various cultural practices, particularly in aromatherapy and perfumery. Scientific evidence suggests potential anti-cancer properties, with studies indicating that patchouli alcohol (PA) can inhibit hepatocellular carcinoma growth through mechanisms involving oxidative stress accumulation and androgen receptor signaling inactivation. Additionally, research has shown that sequencing methods reveal a greater microbial diversity compared to culture-based methods in Pogostemon cablin, though both approaches identified potential pathogens. PA also activates the pregnane X receptor (PXR) to suppress Wnt/β-catenin signaling and epithelial-mesenchymal transition (EMT), which may help inhibit Helicobacter pylori-associated gastric cancer. The essential oil of Pogostemon cablin has demonstrated significant repellency against Aedes aegypti mosquitoes, providing up to 180 minutes of protection. Safety records indicate no major issues have been recorded, and there are currently no known drug interactions associated with this plant.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- PA activates PXR to suppress Wnt/β-catenin signaling and EMT, potentially inhibiting H. pylori-associated gastric cancer.
- The Pogostemon cablin essential oil cream showed significant repellency against Aedes aegypti with a complete protection time of 180 minutes.
- PA inhibited HCC growth through oxidative stress accumulation and androgen receptor signaling inactivation, with potential synergistic effects when combined with sorafenib.
- Sequencing detected far greater microbial diversity compared to culture-based methods in Pogostemon cablin, though both identified potential pathogens.
Frequently asked questions
What is Pogostemon cablin?
Pogostemon cablin (Pogostemon cablin) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Pogostemon cablin?
4 sourced findings are recorded for Pogostemon cablin; the strongest carries evidence grade D. For example: PA activates PXR to suppress Wnt/β-catenin signaling and EMT, potentially inhibiting H. pylori-associated gastric cancer.
How strong is the evidence for Pogostemon cablin?
The strongest finding for Pogostemon cablin carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Pogostemon cablin safe? What are the side effects?
No major safety issues are recorded for Pogostemon cablin in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Pogostemon cablin interact with medications?
No drug interactions are recorded for Pogostemon cablin in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Pogostemon cablin?
Pogostemon cablin is also known as: пачули, Patchouli.
Is Pogostemon cablin a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Microbial profiling of five traditional Chinese medicines: culture-based identification vs. 16S rRNA sequencing. literature abstract metadata
- T2 Inhibitory effects of patchouli alcohol on hepatocellular carcinoma growth through accumulation of oxidative stress and inactivation of androgen receptor signaling. literature abstract metadata
- T2 Development and In Silico/In Vivo Evaluation of a Pogostemon cablin Essential Oil Cream as a Repellent against Aedes aegypti. literature abstract metadata
- T2 Patchouli alcohol suppresses Helicobacter pylori-associated gastric cancer by activating PXR to inhibit the Wnt/β-catenin pathway and EMT. literature abstract metadata