Northeast Asian pasque-flower
Pulsatilla chinensis
Pulsatilla chinensis, also known as Chinese Pasque Flower, is a traditional medicine plant native to China. While its use in traditional practices has not been extensively documented, studies have explored its potential benefits across various contexts. Scientific evidence suggests that Pulsatilla chinensis may offer therapeutic effects through mechanisms such as reducing pro-inflammatory cytokines and enhancing immune function, particularly in dogs with antibiotic-associated diarrhea. Additionally, it shows promise in neurodegenerative models by improving mitochondrial function and reducing Tau phosphorylation. In vitro studies indicate potential anti-cancer properties of 23-hydroxybetulinic acid from Pulsatilla chinensis, which may inhibit esophageal cancer cell proliferation through modulation of BUB1/STAT3 signaling pathways. Safety profiles for this plant are currently favorable with no major issues or recorded drug interactions noted.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- The study identifies four core mechanistic axes of anemoside B4's actions in Pulsatilla chinensis, highlighting context-dependent regulation.
- Pulsatilla chinensis treatment reduced pro-inflammatory cytokines, elevated immune markers, and restored gut microbial diversity in dogs with antibiotic-associated diarrhea.
- Pulsatilla chinensis extract enhanced autophagic flux, reduced Tau phosphorylation, and improved mitochondrial function in neuronal cells and C. elegans models.
- 23-hydroxybetulinic acid from Pulsatilla chinensis inhibited esophageal cancer cell proliferation and induced G2/M phase arrest via downregulating BUB1 and STAT3 signaling.
- HSC-4, a C-28 carboxyl derivative of Hederacoside C, showed significant anti-inflammatory efficacy in murine models without causing hepatotoxicity or nephrotoxicity.
Frequently asked questions
What is Northeast Asian pasque-flower?
Northeast Asian pasque-flower (Pulsatilla chinensis) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Northeast Asian pasque-flower?
5 sourced findings are recorded for Northeast Asian pasque-flower; the strongest carries evidence grade D. For example: The study identifies four core mechanistic axes of anemoside B4's actions in Pulsatilla chinensis, highlighting context-dependent regulation.
How strong is the evidence for Northeast Asian pasque-flower?
The strongest finding for Northeast Asian pasque-flower carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Northeast Asian pasque-flower safe? What are the side effects?
No major safety issues are recorded for Northeast Asian pasque-flower in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Northeast Asian pasque-flower interact with medications?
No drug interactions are recorded for Northeast Asian pasque-flower in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Northeast Asian pasque-flower?
Northeast Asian pasque-flower is also known as: Прострел китайский, Pulsatille de Chine.
Is Northeast Asian pasque-flower a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Targeted degradation of aberrant Tau for the discovery of Pulsatilla chinensis in Alzheimer's disease. literature abstract metadata
- T2 23-hydroxybetulinic acid induces cell cycle arrest in esophageal cancer cells via the BUB1/STAT3 signaling pathway. literature abstract metadata
- T2 Integrated Multi-Omics Analysis Explores the Protective Effects and Potential Mechanisms of Pulsatilla chinensis on Canine Antibiotic-Associated Diarrhea. literature abstract metadata
- T2 Decoding anemoside B4: Core mechanistic axes and an omics-to-atom paradigm. literature abstract metadata
- T2 Design, synthesis, and biological evaluation of C-28 carboxyl derivatives of Hederacoside C as anti-inflammatory agents for acute lung injury. literature abstract metadata