Rhodiola crenulata
Rhodiola crenulata
Rhodiola crenulata is a traditional medicine plant found in regions of Central Asia and Russia. While its specific traditional uses are not well-documented, studies have shown that RSV (a compound from Rhodiola crenulata) may mitigate hepatic fibrosis by upregulating KLF14 expression and downregulating the P2X7r-NLRP3 pathway. Additionally, it has been observed to reduce the accumulation of oxidised phosphatidylcholines in mice with carbon tetrachloride-induced acute hepatic injury. Research also indicates that Rhodiola crenulata-derived rhodiosin can enhance neurological recovery and promote cerebral angiogenesis after stroke through activation of the PI3K/Akt pathway, suggesting potential neuroprotective effects. However, further mechanistic research is needed to fully understand its pharmacological activities. No major safety concerns or recorded drug interactions have been identified thus far.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- RSV mitigates hepatic fibrosis by upregulating KLF14 expression and downregulating the P2X7r-NLRP3 pathway.
- Rhodiola crenulata oligomeric proanthocyanidins pre-treatment reduced the accumulation of oxidised phosphatidylcholines in mice with carbon tetrachloride-induced acute hepatic injury.
- Rhodiosin enhances neurological recovery and cerebral angiogenesis after stroke through PI3K/Akt pathway activation.
- The study found that Rhodiola crenulata exhibits multiple pharmacological activities but notes that research on its mechanism of action needs strengthening.
Frequently asked questions
What is Rhodiola crenulata?
Rhodiola crenulata (Rhodiola crenulata) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Rhodiola crenulata?
4 sourced findings are recorded for Rhodiola crenulata; the strongest carries evidence grade D. For example: RSV mitigates hepatic fibrosis by upregulating KLF14 expression and downregulating the P2X7r-NLRP3 pathway.
How strong is the evidence for Rhodiola crenulata?
The strongest finding for Rhodiola crenulata carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Rhodiola crenulata safe? What are the side effects?
No major safety issues are recorded for Rhodiola crenulata in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Rhodiola crenulata interact with medications?
No drug interactions are recorded for Rhodiola crenulata in our sources. This does not rule them out — check with a pharmacist.
Is Rhodiola crenulata a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Research progress from traditional medicine to chemical composition, pharmacological activity, and clinical application of Rhodiola crenulata. literature abstract metadata
- T2 Rhodiosin promotes cerebral angiogenesis in mice with ischemic stroke via PI3K/Akt pathway activation. literature abstract metadata
- T2 Rapid Lipidomics Analysis of Oxidised Phosphatidylcholines in Carbon Tetrachloride-Induced Acute Hepatic Injury in Mice and Their Regulation by Rhodiola crenulata Oligomeric Proanthocyanidins. literature abstract metadata
- T2 Rosavin mitigates hepatic fibrosis via KLF14-mediated suppression of P2X7 receptor-dependent inflammatory signaling cascades. literature abstract metadata