Siler
Saposhnikovia divaricata
Saposhnikovia divaricata, commonly known as Fángfēng in traditional Chinese medicine, is traditionally used for its purported anti-inflammatory and immune-stimulating properties. However, no specific traditional uses have been recorded. Scientific evidence suggests that Saposhnikovia divaricata may enhance plant growth under certain conditions and alter the rhizosphere microbiome. Additionally, extracts from Yupingfeng San, a formula containing Saposhnikovia divaricata, have shown renoprotective effects in models of renal interstitial fibrosis. Furthermore, compounds derived from Saposhnikovia divaricata, such as CHR and Prim-O-glucosylcimifugin, may modulate immune cell polarization and ameliorate rheumatoid arthritis by targeting specific pathways. To date, no major safety issues or drug interactions have been reported for this plant.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- CHR from Saposhnikovia divaricata modulate M1 macrophage polarization and ameliorate RA by targeting CBLL1, though the exact mechanism remains partially elucidated.
- Inoculation with Aspergillus neoalliaceus MR-86 increased Saposhnikovia divaricata growth and altered its rhizosphere microbiome.
- Yupingfeng San extract showed renoprotective effects in cisplatin-induced renal interstitial fibrosis by modulating IL-6/JAK/STAT3 pathway and mitochondrial homeostasis.
- Saposhnikovia divaricata-derived Prim-O-glucosylcimifugin ameliorates rheumatoid arthritis by targeting GBP5 to suppress pyroptosis and inhibit synovial cell proliferation.
Frequently asked questions
What is Siler?
Siler (Saposhnikovia divaricata) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Siler?
4 sourced findings are recorded for Siler; the strongest carries evidence grade D. For example: CHR from Saposhnikovia divaricata modulate M1 macrophage polarization and ameliorate RA by targeting CBLL1, though the exact mechanism remains partially elucidated.
How strong is the evidence for Siler?
The strongest finding for Siler carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Siler safe? What are the side effects?
No major safety issues are recorded for Siler in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Siler interact with medications?
No drug interactions are recorded for Siler in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Siler?
Siler is also known as: Сапожниковия растопыренная.
Is Siler a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Chromones from Saposhnikovia divaricata modulate m6A RNA methylation-mediated macrophage polarization by targeting CBLL1 to ameliorate RA. literature abstract metadata
- T2 Yupingfeng San extract ameliorates cisplatin induced renal interstitial fibrosis via IL-6/JAK/STAT3 mediated restoration of mitochondrial homeostasis. literature abstract metadata
- T2 Prim-O-glucosylcimifugin ameliorates rheumatoid arthritis by targeting GBP5 to suppress pyroptosis and inhibit synovial cell proliferation. literature abstract metadata
- T2 Aspergillus neoalliaceus MR-86 Promotes the Growth of Saposhnikovia divaricata by Regulating the Rhizosphere Microbiome. literature abstract metadata