East Asian groundsel
Tephroseris kirilowii
Tephroseris kirilowii is a plant species traditionally not associated with any known medicinal practices. Scientific research indicates that its distribution and population richness vary among different vegetation types, with higher diversity observed in caragana shrubland compared to saline grassland. While there are no reported traditional uses or extensive scientific studies focusing on Tephroseris kirilowii for medicinal purposes, some flavonoids derived from the plant have shown potential biological activity, including modulation of autophagy and apoptosis pathways. These findings suggest that certain compounds may exhibit anti-proliferative effects in human breast cancer cells through PI3Kγ-mediated signaling downregulation. To date, no significant safety concerns or drug interactions have been recorded for Tephroseris kirilowii.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- Three flavonoids from Tephroseris kirilowii inhibited cell proliferation and induced apoptosis and autophagy through downregulating PI3Kγ-mediated signaling in human breast cancer cells.
- Species composition differed significantly among vegetation types, with the highest richness found in caragana shrubland and the lowest in saline grassland.
- The study found that Japanese populations of Tephroseris kirilowii diverged from continental East Asian populations around 25,000 years ago, with post-glacial expansion indicated.
- Tephroseris kirilowii flavonoids were found to modulate autophagy, apoptosis, and the cell cycle.
Frequently asked questions
What is East Asian groundsel?
East Asian groundsel (Tephroseris kirilowii) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about East Asian groundsel?
4 sourced findings are recorded for East Asian groundsel; the strongest carries evidence grade D. For example: Three flavonoids from Tephroseris kirilowii inhibited cell proliferation and induced apoptosis and autophagy through downregulating PI3Kγ-mediated signaling in human breast cancer cells.
How strong is the evidence for East Asian groundsel?
The strongest finding for East Asian groundsel carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is East Asian groundsel safe? What are the side effects?
No major safety issues are recorded for East Asian groundsel in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does East Asian groundsel interact with medications?
No drug interactions are recorded for East Asian groundsel in our sources. This does not rule them out — check with a pharmacist.
What are the common names of East Asian groundsel?
East Asian groundsel is also known as: Пепельник Кирилова.
Is East Asian groundsel a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Flavonoids inhibit cell proliferation and induce apoptosis and autophagy through downregulation of PI3Kγ mediated PI3K/AKT/mTOR/p70S6K/ULK signaling pathway in human breast cancer cells. literature abstract metadata
- T2 A review of biologically active flavonoids as inducers of autophagy and apoptosis in neoplastic cells and as cytoprotective agents in non-neoplastic cells. literature abstract metadata
- T2 Phylogeography of the temperate grassland plant Tephroseris kirilowii (Asteraceae) inferred from multiplexed inter-simple sequence repeat genotyping by sequencing (MIG-seq) data. literature abstract metadata
- T2 Canopy-Mediated Shifts in Grassland Diversity and Heterogeneity: A Power Law Approach from China's Loess Plateau. literature abstract metadata