FolkKB

Triclisia

Triclisia

Triclisia is a plant with traditional medicine roots, though specific uses are not documented. Scientific studies have identified bioactive compounds such as phenols, fatty acids, vitamins, steroids, kaempferol, and dihydrovomifoliol-O-glucoside in the aqueous methanolic leaf extract of Triclisia gilletii. Research indicates potential anti-amoebic activity against Entamoeba histolytica; however, the evidence is currently limited by high bias risk among some studies. Additionally, cycleanine from Triclisia subcordata has shown in vitro and in vivo antimalarial activity with improved potency in semisynthetic analogues, and two novel (aminoalkyl)cycleanine analogues demonstrated greater efficacy in inducing apoptosis in ovarian cancer cells. No significant safety concerns or recorded drug interactions have been identified to date.

At a glance
Best evidence
A
Cautions
—

Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.

What the science says

  • The aqueous methanolic leaf extract of Triclisia gilletii contains phenols, fatty acids, vitamins, steroids, kaempferol, and dihydrovomifoliol-O-glucoside. D PMID
  • The study identified 42 herbs with anti-amoebic activity but noted only seven medicinal plants showed the most potent activity based on IC50 values. A PMID
  • Cycleanine and its semisynthetic analogues showed in vitro antiplasmodial activity and improved efficacy in vivo against malaria. D PMID
  • The study synthesized and tested novel (aminoalkyl)cycleanine analogues, finding them to be more potent than cycleanine in inducing apoptosis in ovarian cancer cells. D PMID

Frequently asked questions

What is Triclisia?

Triclisia (Triclisia) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.

What does the scientific evidence say about Triclisia?

4 sourced findings are recorded for Triclisia; the strongest carries evidence grade A. For example: The aqueous methanolic leaf extract of Triclisia gilletii contains phenols, fatty acids, vitamins, steroids, kaempferol, and dihydrovomifoliol-O-glucoside.

How strong is the evidence for Triclisia?

The strongest finding for Triclisia carries evidence grade A — strong evidence. Grades run A (strongest) to D (preliminary or traditional).

Is Triclisia safe? What are the side effects?

No major safety issues are recorded for Triclisia in our sources, but the data may be incomplete. Consult a qualified professional before use.

Does Triclisia interact with medications?

No drug interactions are recorded for Triclisia in our sources. This does not rule them out — check with a pharmacist.

Is Triclisia a proven treatment?

No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.

Sources

  1. T2 Synthesis of (aminoalkyl)cycleanine analogues: cytotoxicity, cellular uptake, and apoptosis induction in ovarian cancer cells. literature abstract metadata
  2. T2 Phytochemical profiling of aqeous methanolic leaf extract of Triclisia gilletii by gas chromatography (GC/MS) and liquid chromatography (HPLC-PDA-ESI/MSn) tandem mass spectroscopy (MS): a pointer to its nephroprotection. literature abstract metadata
  3. T2 In Vivo Efficacy and Metabolism of the Antimalarial Cycleanine and Improved In Vitro Antiplasmodial Activity of Semisynthetic Analogues. literature abstract metadata
  4. T2 A systematic review of anti-Entamoeba histolytica activity of medicinal plants published in the last 20 years. literature abstract metadata