Regel’s threewingnut
Tripterygium regelii
Tripterygium regelii, a plant native to China and other parts of Asia, has not been traditionally used for medicinal purposes. Recent scientific studies have shown promising results; extracts from its bark demonstrated potent activity against SARS-CoV 3CLpro with an IC50 value of 2.6 ± 0.6 μmol L-1, indicating potential antiviral efficacy. Additionally, terpenoids identified from the roots of Tripterygium regelii showed potential anti-colorectal cancer effects by inducing ferroptosis in one new compound. Compounds 7 and 13 from the same plant roots exhibited significant anti-inflammatory activity through activation of AHR and inhibition of several signaling pathways. Notably, invasion by this plant is observed after the death of A. nephrolepis in forest gaps, which may affect tree regeneration. Safety concerns are currently unreported, with no major issues recorded to date. There have been no documented drug interactions associated with Tripterygium regelii as of now.
- Best evidence
- A
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- Tripterygium regelii bark extracts showed potent activity against SARS-CoV 3CLpro with an IC50 of 2.6 ± 0.6 μmol L-1.
- The study identified terpenoids from Tripterygium regelii roots, with one new compound showing potential anti-colorectal cancer efficacy by inducing ferroptosis.
- Compounds 7 and 13 from Tripterygium regelii roots showed significant anti-inflammatory activity by activating AHR and inhibiting several signaling pathways.
- Tripterygium regelii invasion is observed after the death of A. nephrolepis in forest gaps, potentially hindering tree regeneration.
Frequently asked questions
What is Regel’s threewingnut?
Regel’s threewingnut (Tripterygium regelii) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Regel’s threewingnut?
4 sourced findings are recorded for Regel’s threewingnut; the strongest carries evidence grade A. For example: Tripterygium regelii bark extracts showed potent activity against SARS-CoV 3CLpro with an IC50 of 2.6 ± 0.6 μmol L-1.
How strong is the evidence for Regel’s threewingnut?
The strongest finding for Regel’s threewingnut carries evidence grade A — strong evidence. Grades run A (strongest) to D (preliminary or traditional).
Is Regel’s threewingnut safe? What are the side effects?
No major safety issues are recorded for Regel’s threewingnut in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Regel’s threewingnut interact with medications?
No drug interactions are recorded for Regel’s threewingnut in our sources. This does not rule them out — check with a pharmacist.
Is Regel’s threewingnut a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Medicinal plants with anti-SARS-CoV activity repurposing for treatment of COVID-19 infection: A systematic review and meta-analysis. literature abstract metadata
- T2 Pre-drought effects on northern temperate trees and vine invasion in forest gaps hindering regeneration. literature abstract metadata
- T2 Macrolide sesquiterpene pyridine alkaloids from the roots of Tripterygium regelii and their anti-inflammatory activity. literature abstract metadata
- T2 Diterpenoids and triterpenoids from the roots of Tripterygium regelii and their inhibitory effects on colorectal cancer cells. literature abstract metadata