Bootlace Plant
Wikstroemia indica
Wikstroemia indica, a plant traditionally used in Asian medicine, particularly in Ayurveda and traditional Chinese medicine, though specific uses are not well-documented. Scientific studies have shown promising results with daphnoretin, an active compound from the plant, demonstrating anti-cancer properties by inhibiting colorectal cancer cell proliferation and migration. Additionally, eight compounds isolated from Wikstroemia indica were found to reduce inflammation and inhibit NF-κB pathway activation in spinal cord injury mice models. Climate change is expected to expand its suitable habitat area northwestward in China. No significant safety concerns or drug interactions have been recorded for this plant.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- Daphnoretin (from Wikstroemia indica) suppresses colorectal cancer cell proliferation and migration by enhancing P53 ubiquitination through HSP90AA1 targeting.
- Eight compounds were isolated from Wikstroemia indica, with one significantly reducing IL-1β secretion in macrophages.
- Daphnoretin inhibited inflammation and NF-κB pathway activation in spinal cord injury mice.
- The study found that climate change is projected to significantly expand and shift the suitable habitat area of Wikstroemia indica northwestward in China.
Frequently asked questions
What is Bootlace Plant?
Bootlace Plant (Wikstroemia indica) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Bootlace Plant?
4 sourced findings are recorded for Bootlace Plant; the strongest carries evidence grade D. For example: Daphnoretin (from Wikstroemia indica) suppresses colorectal cancer cell proliferation and migration by enhancing P53 ubiquitination through HSP90AA1 targeting.
How strong is the evidence for Bootlace Plant?
The strongest finding for Bootlace Plant carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Bootlace Plant safe? What are the side effects?
No major safety issues are recorded for Bootlace Plant in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Bootlace Plant interact with medications?
No drug interactions are recorded for Bootlace Plant in our sources. This does not rule them out — check with a pharmacist.
Is Bootlace Plant a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Daphnoretin inhibited SCI-induced inflammation and activation of NF-κB pathway in spinal dorsal horn. literature abstract metadata
- T2 Lignans and neolignans from the twigs and leaves of Wikstroemia indica (L.) C.A. Mey. with their effects on LPS-induced IL-1β and IL-10 secretion in RAW 264.7 macrophages. literature abstract metadata
- T2 Projected Expansion and Northwestern Shift of Wikstroemia indica Suitable Habitats in China Under Multiple Climate Change Scenarios: An Optimized MaxEnt Approach. literature abstract metadata
- T2 Daphnoretin targeted binding to HSP90AA1 to promote P53 UFMylation and stability thereby inducing apoptosis in colorectal cancer. literature abstract metadata