Asian Bittersweet
Celastrus orbiculatus
Celastrus orbiculatus, traditionally not used in any known medical practices, has shown promise in scientific research. Studies indicate its potential for inhibiting cancer stem cell proliferation across various cancers through mechanisms such as disrupting the TGF-β/Smad pathway. Additionally, it has demonstrated antibacterial activity and optimized extraction methods have been developed to enhance triterpenoid yields from the plant's roots. In another study, pristimerin ameliorated gastric mucosal damage in mice, while celafolin A-1 reduced α-SMA and VEGF expression, decreasing CNV areas in a laser-induced choroidal neovascularization model. To date, no major safety issues or drug interactions have been recorded for Celastrus orbiculatus, but further research is needed to fully understand its potential applications and effects.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- Celafolin A-1 reduced α-SMA and VEGF expression, decreased CNV areas, and regulated Cryab phosphorylation in a mouse model of laser-induced choroidal neovascularization.
- Celastrus orbiculatus shows promise in inhibiting cancer stem cell proliferation across various cancers, though more rigorous clinical trials are needed.
- The study optimized an ultrasound-assisted extraction method for triterpenoids from Celastrus orbiculatus roots, achieving higher yields and significant antibacterial activity.
- Pristimerin ameliorates gastric mucosal damage and oxyntic atrophy in high-dose tamoxifen-induced SPEM mice by modulating Cdkn1c-mediated glycolytic reprogramming.
Frequently asked questions
What is Asian Bittersweet?
Asian Bittersweet (Celastrus orbiculatus) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Asian Bittersweet?
4 sourced findings are recorded for Asian Bittersweet; the strongest carries evidence grade D. For example: Celafolin A-1 reduced α-SMA and VEGF expression, decreased CNV areas, and regulated Cryab phosphorylation in a mouse model of laser-induced choroidal neovascularization.
How strong is the evidence for Asian Bittersweet?
The strongest finding for Asian Bittersweet carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Asian Bittersweet safe? What are the side effects?
No major safety issues are recorded for Asian Bittersweet in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Asian Bittersweet interact with medications?
No drug interactions are recorded for Asian Bittersweet in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Asian Bittersweet?
Asian Bittersweet is also known as: Древогубец круглолистный, Bourreau des arbres asiatique.
Is Asian Bittersweet a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Celafolin A-1 Ameliorates Subretinal Fibrosis via Inhibition of Crystallin Alpha B in a Laser-Induced Choroidal Neovascularization Mouse Model. literature abstract metadata
- T2 Cancer Stem Cells and Medicinal Plants, A Comprehensive Review of their Potential in Tumor Suppression and Recurrence Prevention. literature abstract metadata
- T2 Pristimerin ameliorates spasmolytic polypeptide-expressing metaplasia by modulating Cdkn1c (p57)-mediated glycolytic reprogramming. literature abstract metadata
- T2 Ultrasound-assisted supramolecular solvent extraction with enzymatic pretreatment of Celastrus orbiculatus roots: Process optimization, enrichment, and antibacterial activity. literature abstract metadata