Glycyrrhiza uralensis

Glycyrrhiza uralensis, commonly known as licorice root, is a traditional plant used in various Asian and European herbal practices. Its specific uses are not well-documented in historical records; however, it has been employed for its purported medicinal properties such as anti-inflammatory and antitussive effects. Scientific evidence suggests that Glycyrrhiza uralensis may influence gut microbiota and host responses in models of antibiotic-associated diarrhea, showing mixed results with some formulations supporting microbial recovery while others exhibit pathogen control. Additionally, research indicates that Piriformospora indica colonization can enhance the growth, stress resistance, and medicinal compound accumulation of Glycyrrhiza uralensis under salt stress conditions. In agricultural settings, partial organic fertilizer substitution has been shown to alter soil gene abundance related to carbon and nitrogen cycling, potentially affecting the plant's growth traits. Notably, in cardiac health studies, Qishen paste containing Glycyrrhiza uralensis improved cardiac conduction and function by upregulating Cx43 in cardiac resident macrophages in heart failure mice models. Safety concerns for Glycyrrhiza uralensis are minimal with no major issues recorded; however, due to its high glycyrrhizin content, prolonged use or high doses may lead to side effects such as hypertension and electrolyte imbalances. There is currently no reported evidence of significant drug interactions.

Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.