Hypericum
Hypericum
Hypericum is a genus of plants traditionally used in various herbal practices. Hypericum perforatum L., commonly known as St. John's Wort, has been studied for its potential antidepressant effects and is used in some traditional medicine systems to address depressive symptoms. Scientific evidence suggests that both H. perforatum and Chaihu Shugan San may alleviate depressive-like behaviors through different mechanisms but with overlapping pathways. Additionally, research indicates that H. perforatum and Glycyrrhiza glabra can preserve cardiac mitochondrial redox homeostasis in estrogen deficiency by modulating MAO-A and ERβ activity, while H. perforatum and Achillea millefolium essential oils show synergistic antibacterial effects against Staphylococcus epidermidis in specific oil combinations. Hypericum extracts also demonstrated significant sleep-promoting effects in mice, possibly through adenosine and melatonin receptor signaling. No major safety concerns or drug interactions have been recorded for Hypericum use to date.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- Both Hypericum perforatum L. (St. John's Wort) and Chaihu Shugan San alleviated depressive-like behaviors through distinct yet partially overlapping molecular mechanisms.
- Hypericum perforatum and Glycyrrhiza glabra preserved cardiac mitochondrial redox homeostasis in estrogen deficiency by modulating MAO-A and ERβ.
- Hypericum perforatum and Achillea millefolium essential oils showed synergistic activity against Staphylococcus epidermidis in specific oil combinations.
- HME significantly reduced sleep onset latency and prolonged total sleep time in mice, suggesting effects mediated through adenosine and melatonin receptor signaling.
- Hypericum triquetrifolium hydroalcoholic extract shows strong antioxidant and anti-inflammatory activity, with selective cytotoxicity against pancreatic cancer cells.
Frequently asked questions
What is Hypericum?
Hypericum (Hypericum) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Hypericum?
5 sourced findings are recorded for Hypericum; the strongest carries evidence grade D. For example: Both Hypericum perforatum L. (St. John's Wort) and Chaihu Shugan San alleviated depressive-like behaviors through distinct yet partially overlapping molecular mechanisms.
How strong is the evidence for Hypericum?
The strongest finding for Hypericum carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Hypericum safe? What are the side effects?
No major safety issues are recorded for Hypericum in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Hypericum interact with medications?
No drug interactions are recorded for Hypericum in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Hypericum?
Hypericum is also known as: Зверобой, millepertuis.
Is Hypericum a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Chemical Composition and Synergistic Antimicrobial Activity of Hypericum perforatum and Achillea millefolium Essential Oils Against Wound-Associated Microorganisms. literature abstract metadata
- T2 In Vitro Evidence for the Dual Antioxidant and Anti-Inflammatory Roles of Hypericum triquetrifolium in Cancer Therapy: Selective Cytotoxicity Against Pancreatic Cancer Cells. literature abstract metadata
- T2 Hypericum perforatum L. and Glycyrrhiza glabra L. preserve cardiac mitochondrial redox homeostasis in E2 deficiency via ERβ-MAO-A modulation. literature abstract metadata
- T2 Integrative Proteomics Reveals Distinct Lipid Metabolic and Gut Microbiota-Associated Antidepressant Mechanisms of Two Herbal Medicines in a Chronic Stress Model. literature abstract metadata
- T2 Hypnotic Effects of Hypericum perforatum L. and Melissa officinalis L. Through Adenosine and Melatonin Receptors. literature abstract metadata