Tree peony
Paeonia suffruticosa
Paeonia suffruticosa, commonly known as tree peony, is a traditional medicinal plant with roots in East Asian medicine. While its specific uses are not well-documented in historical traditions, studies have shown that compounds such as paeonol may suppress prostate cancer progression by regulating the miR-145-5p/GOLM1 axis. Quercetin, an active ingredient found in Cortex Moutan (the root of Paeonia suffruticosa), has demonstrated anti-kidney injury effects through its ability to reduce reactive oxygen species levels and inhibit AKT1 and NF-κB pathways. Research also indicates that the rhizosphere of Paeonia suffruticosa 'Luoyang Hong' undergoes significant microbial and metabolite changes over a 12- to 42-year period, with shifts in beneficial bacteria and degradation-related genera. Additionally, PsEXPA4-1 has been identified as a key expansin promoting flower opening in tree peonies, regulated by gibberellin via PsbHLH25. To date, no major safety issues or drug interactions have been recorded for Paeonia suffruticosa.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- The study identified quercetin as a key active ingredient from Cortex Moutan that shows anti-kidney injury effects by targeting the AKT1 and NF-κB pathways.
- The study found that the rhizosphere of Paeonia suffruticosa 'Luoyang Hong' showed distinct microbial and metabolite changes over a 12- to 42-year chronosequence, with declining beneficial bacteria and increasing degradation-related genera.
- Paeonol suppresses prostate cancer progression by regulating the miR-145-5p/GOLM1 axis.
- This study identified PsEXPA4-1 as a key expansin promoting tree peony flower opening, potentially through GA signaling.
Frequently asked questions
What is Tree peony?
Tree peony (Paeonia suffruticosa) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Tree peony?
4 sourced findings are recorded for Tree peony; the strongest carries evidence grade D. For example: The study identified quercetin as a key active ingredient from Cortex Moutan that shows anti-kidney injury effects by targeting the AKT1 and NF-κB pathways.
How strong is the evidence for Tree peony?
The strongest finding for Tree peony carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Tree peony safe? What are the side effects?
No major safety issues are recorded for Tree peony in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Tree peony interact with medications?
No drug interactions are recorded for Tree peony in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Tree peony?
Tree peony is also known as: Пион древовидный, pivoine en arbre.
Is Tree peony a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Identification of the PsEXP Gene Family and Functional Analysis of PsEXPA4-1 During Flower Opening Process in Tree Peony (Paeonia suffruticosa). literature abstract metadata
- T2 Metagenomic and metabolomic insights into the rhizosphere of Paeonia suffruticosa 'Luoyang Hong' across a continuous cropping chronosequence. literature abstract metadata
- T2 Exploring the Mechanisms Underlying the Effects of Cortex Moutan and Its Active Ingredients on Kidney Injury Through Network Pharmacology and Experimental Validation. literature abstract metadata
- T2 Paeonol inhibits prostate cancer progression via the miR-145-5p/GOLM1 axis. literature abstract metadata