Pasqueflower
Pulsatilla
Pulsatilla is a plant traditionally used in East Asian medicine, particularly in Chinese herbalism. It has been employed for various conditions but specific traditional uses are not well-documented. Scientific evidence suggests that anemoside B4 from Pulsatilla chinensis may have anti-inflammatory effects and can inhibit the proliferation of esophageal cancer cells through mechanisms involving downregulation of BUB1 and STAT3 signaling. Additionally, a C-28 carboxyl derivative of Hederacoside C showed significant anti-inflammatory efficacy in murine models without causing notable toxicity. A study also indicated that Pulsatilla chinensis treatment can reduce inflammation and restore gut microbial diversity in dogs with antibiotic-associated diarrhea. However, the strength of these findings is currently limited by the lack of extensive human studies or specific dose recommendations. No major safety issues or drug interactions have been recorded for this plant.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- Pulsatilla chinensis treatment reduced pro-inflammatory cytokines, elevated immune markers, and restored gut microbial diversity in dogs with antibiotic-associated diarrhea.
- The study identifies four core mechanistic axes of anemoside B4's actions in Pulsatilla chinensis, highlighting context-dependent regulation.
- 23-hydroxybetulinic acid inhibited esophageal cancer cell proliferation and induced G2/M phase arrest via downregulating BUB1 and STAT3 signaling.
- HSC-4, a C-28 carboxyl derivative of Hederacoside C, showed significant anti-inflammatory efficacy in murine models without causing hepatotoxicity or nephrotoxicity.
- Caltha scaposa's chloroplast genome shows a typical quadripartite structure with unique IR boundaries compared to related Pulsatilla species.
Frequently asked questions
What is Pasqueflower?
Pasqueflower (Pulsatilla) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Pasqueflower?
5 sourced findings are recorded for Pasqueflower; the strongest carries evidence grade D. For example: Pulsatilla chinensis treatment reduced pro-inflammatory cytokines, elevated immune markers, and restored gut microbial diversity in dogs with antibiotic-associated diarrhea.
How strong is the evidence for Pasqueflower?
The strongest finding for Pasqueflower carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Pasqueflower safe? What are the side effects?
No major safety issues are recorded for Pasqueflower in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Pasqueflower interact with medications?
No drug interactions are recorded for Pasqueflower in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Pasqueflower?
Pasqueflower is also known as: прострел, Pulsatille.
Is Pasqueflower a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 23-hydroxybetulinic acid induces cell cycle arrest in esophageal cancer cells via the BUB1/STAT3 signaling pathway. literature abstract metadata
- T2 Integrated Multi-Omics Analysis Explores the Protective Effects and Potential Mechanisms of Pulsatilla chinensis on Canine Antibiotic-Associated Diarrhea. literature abstract metadata
- T2 Decoding anemoside B4: Core mechanistic axes and an omics-to-atom paradigm. literature abstract metadata
- T2 Comparative Analysis of Complete Chloroplast Genomes of Caltha scaposa for Identification and Phylogenetic Analysis. literature abstract metadata
- T2 Design, synthesis, and biological evaluation of C-28 carboxyl derivatives of Hederacoside C as anti-inflammatory agents for acute lung injury. literature abstract metadata