Stephania venosa
Stephania venosa
Stephania venosa, a plant traditionally used in certain herbal practices but with no specific traditional uses recorded, has shown promise in scientific research. Studies have indicated that crebanine from Stephania venosa can significantly inhibit RCC colonies and cause G1-phase cell-cycle arrest, leading to suppressed cell proliferation and cell death. Additionally, the alkaloids crebanine (CN) and O-methylbulbocapnine (OMBC) enhance cisplatin sensitivity in SKOV3 ovarian cancer cells by inhibiting Akt/NF-κB signaling. These findings suggest potential anti-cancer properties, particularly against hepatocellular carcinoma and ovarian cancer. While no major safety issues or drug interactions have been recorded, the scientific evidence is currently limited and more research is needed to fully understand its efficacy and applications.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- Crebanine significantly inhibited renal cell carcinoma colonies and induced G1-phase arrest with sub-G1 accumulation, leading to suppressed proliferation and apoptosis.
- Crebanine from Stephania venosa suppresses hepatocellular carcinoma proliferation and invasion by modulating the EZH2/DUSP1/Akt signaling pathway.
- OMP and DC suppressed LPS-induced inflammatory response in RAW264.7 macrophages by inhibiting NF-κB and AP-1 activation.
- CN and OMBC enhance cisplatin sensitivity in SKOV3 ovarian cancer cells by inhibiting Akt/NF-κB signaling.
Frequently asked questions
What is Stephania venosa?
Stephania venosa (Stephania venosa) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Stephania venosa?
4 sourced findings are recorded for Stephania venosa; the strongest carries evidence grade D. For example: Crebanine significantly inhibited renal cell carcinoma colonies and induced G1-phase arrest with sub-G1 accumulation, leading to suppressed proliferation and apoptosis.
How strong is the evidence for Stephania venosa?
The strongest finding for Stephania venosa carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Stephania venosa safe? What are the side effects?
No major safety issues are recorded for Stephania venosa in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Stephania venosa interact with medications?
No drug interactions are recorded for Stephania venosa in our sources. This does not rule them out — check with a pharmacist.
Is Stephania venosa a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Alkaloids from Stephania venosa as Chemo-Sensitizers in SKOV3 Ovarian Cancer Cells via Akt/NF-κB Signaling. literature abstract metadata
- T2 O-Methylbulbocapnine and Dicentrine Suppress LPS-Induced Inflammatory Response by Blocking NF-κB and AP-1 Activation through Inhibiting MAPKs and Akt Signaling in RAW264.7 Macrophages. literature abstract metadata
- T2 Crebanine Induces Cell Death and Alters the Mitotic Process in Renal Cell Carcinoma In Vitro. literature abstract metadata
- T2 EZH2/DUSP1/Akt signaling axis mediates the inhibitory effect of crebanine on hepatocellular carcinoma progression. literature abstract metadata