False Ohelo
Wikstroemia
Wikstroemia is a plant traditionally not associated with any specific medicinal uses. Scientific research has identified eight bioactive compounds from Wikstroemia indica, one of which, daphnoretin, shows promise in suppressing colorectal cancer cell proliferation and migration by enhancing P53 ubiquitination through HSP90AA1 targeting. Climate change is expected to alter the geographical distribution of Wikstroemia indica, expanding its suitable habitat area northwestward in China. The chloroplast genomes from several Daphne species have been sequenced, providing new insights into the genus's phylogenetics but not directly related to Wikstroemia. No significant safety concerns or known drug interactions are recorded for this plant.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- Eight compounds were isolated from Wikstroemia indica, with one significantly reducing IL-1β secretion in macrophages.
- Daphnoretin (from Wikstroemia indica) suppresses colorectal cancer cell proliferation and migration by enhancing P53 ubiquitination through HSP90AA1 targeting.
- The study sequenced and analyzed chloroplast genomes from several Daphne species, revealing substantial variation and providing new insights into the genus's phylogenetics.
- The study found that climate change is projected to significantly expand and shift the suitable habitat area for Wikstroemia indica northwestward in China.
Frequently asked questions
What is False Ohelo?
False Ohelo (Wikstroemia) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about False Ohelo?
4 sourced findings are recorded for False Ohelo; the strongest carries evidence grade D. For example: Eight compounds were isolated from Wikstroemia indica, with one significantly reducing IL-1β secretion in macrophages.
How strong is the evidence for False Ohelo?
The strongest finding for False Ohelo carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is False Ohelo safe? What are the side effects?
No major safety issues are recorded for False Ohelo in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does False Ohelo interact with medications?
No drug interactions are recorded for False Ohelo in our sources. This does not rule them out — check with a pharmacist.
Is False Ohelo a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Evolutionary dynamics of the chloroplast genome in Daphne (Thymelaeaceae): comparative analysis with related genera and insights into phylogenetics. literature abstract metadata
- T2 Lignans and neolignans from the twigs and leaves of Wikstroemia indica (L.) C.A. Mey. with their effects on LPS-induced IL-1β and IL-10 secretion in RAW 264.7 macrophages. literature abstract metadata
- T2 Projected Expansion and Northwestern Shift of Wikstroemia indica Suitable Habitats in China Under Multiple Climate Change Scenarios: An Optimized MaxEnt Approach. literature abstract metadata
- T2 Daphnoretin targeted binding to HSP90AA1 to promote P53 UFMylation and stability thereby inducing apoptosis in colorectal cancer. literature abstract metadata