Licorice
Glycyrrhiza
Glycyrrhiza, commonly known as licorice, originates from traditional medicine practices in various regions, including Anatolia. It has been traditionally used for its purported benefits in managing acute and chronic respiratory conditions through unspecified bioactive mechanisms. Scientific evidence suggests potential cognitive benefits associated with herbal medicines containing Glycyrrhiza glabra, though more standardized research is required to confirm these findings. A study indicated that Qishen paste, which includes Glycyrrhiza, may improve cardiac conduction and function in heart failure mice by upregulating Cx43 in cardiac resident macrophages. Liquiritin from Codonopsis pilosula-Glycyrrhiza uralensis extract showed potential in alleviating weaning stress but more research is needed to validate these effects. No major safety issues or drug interactions have been recorded for Glycyrrhiza, though further investigation is recommended due to the limited evidence available.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- The study found that traditional Anatolian plants, including Glycyrrhiza glabra, are associated with both acute and chronic respiratory conditions through various bioactive mechanisms.
- Preclinical and some clinical evidence suggests that Glycyrrhiza glabra may have potential cognitive benefits through multiple mechanisms, but more standardized research is needed.
- The study identified potential bioactive compounds from Glycyrrhiza glabra and other plants that interact with targets related to respiratory diseases, suggesting multifactorial actions but requiring further experimental validation.
- Amorfrutin-A, derived from Glycyrrhiza foetida, showed strong antibacterial activity against multidrug-resistant Staphylococcus aureus without significant cytotoxicity or detectable resistance development.
- Qishen paste improved cardiac function and conduction in heart failure mice by upregulating Cx43 in cardiac resident macrophages.
- The study found that liquiritin from Codonopsis pilosula-Glycyrrhiza uralensis extract showed potential in alleviating weaning stress by interacting with alpha-1-microglobulin/bikunin precursor.
Frequently asked questions
What is Licorice?
Licorice (Glycyrrhiza) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Licorice?
6 sourced findings are recorded for Licorice; the strongest carries evidence grade D. For example: The study found that traditional Anatolian plants, including Glycyrrhiza glabra, are associated with both acute and chronic respiratory conditions through various bioactive mechanisms.
How strong is the evidence for Licorice?
The strongest finding for Licorice carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Licorice safe? What are the side effects?
No major safety issues are recorded for Licorice in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Licorice interact with medications?
No drug interactions are recorded for Licorice in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Licorice?
Licorice is also known as: Солодка, Réglisse.
Is Licorice a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Traditional Respiratory Remedies From Anatolia: Ethnobotanical Insights and Bioactive Properties. literature abstract metadata
- T2 Amorfrutin-A, a membrane-targeting phytochemical active against multidrug-resistant Staphylococcus aureus: In vitro and in vivo activity and mechanism of action. literature abstract metadata
- T2 Network pharmacology-based therapeutic illustration of Indian medicinal plants in respiratory disorders. literature abstract metadata
- T2 Mechanism of liquiritin from Codonopsis pilosula-Glycyrrhiza uralensis extract in alleviating piglet weaning stress via binding to alpha-1-microglobulin/bikunin precursor by machine learning and molecular dynamics simulation. literature abstract metadata
- T2 Qishen Paste Improves Cardiac Conduction in Heart Failure by Regulating Cardiac Resident Macrophage Connexin43. literature abstract metadata
- T2 Herbal Neurotherapeutics for Cognitive Disorders: Integrative Mechanisms Linking Neurotransmitter Systems, Neurodegeneration, and the Gut-Brain Axis. literature abstract metadata