Paeony
Paeonia
Paeonia is a traditional medicinal plant with roots in East Asian herbal medicine. Traditionally, it has been used for various conditions such as menstrual cramps and liver disorders, though specific uses vary among different traditions. Scientific evidence suggests that paeonol from Paeonia lactiflora can suppress prostate cancer progression by regulating the miR-145-5p/GOLM1 axis. Additionally, paeoniflorin has shown potential in reducing inflammation associated with osteoarthritis through upregulating SOCS3 expression in macrophages. Extracellular vesicles derived from Paeonia lactiflora have been found to improve diabetic peripheral neuropathy by modulating CCL21/CCR7 signaling and reducing Schwann cell injury and neuroinflammation. Albiflorin, another compound from the plant, has demonstrated multiple pharmacological activities including anti-inflammatory, neuroprotective, and hepatoprotective effects, though its oral bioavailability remains a challenge for therapeutic applications. No major safety issues or drug interactions have been recorded for Paeonia.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- Paeonol suppresses prostate cancer progression by regulating the miR-145-5p/GOLM1 axis.
- Paeoniflorin upregulated SOCS3 expression in macrophages, potentially reducing inflammation in a mouse model of OA.
- Paeonia lactiflora-derived extracellular vesicles improve diabetic peripheral neuropathy by modulating CCL21/CCR7 signaling, reducing Schwann cell injury and neuroinflammation.
- Albiflorin showed multiple pharmacological activities including anti-inflammatory, neuroprotective, and hepatoprotective effects, but optimal oral bioavailability remains uncertain.
- Three cultivars, 'Red Charm', 'Bartzella', and 'Sarah Bernhardt', showed stronger relative salt tolerance under severe stress conditions.
- Three novel monoterpenoids were isolated from Paeonia lactiflora roots and showed significant neuroprotective effects against H2O2-induced injury in PC12 cells.
Frequently asked questions
What is Paeony?
Paeony (Paeonia) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Paeony?
6 sourced findings are recorded for Paeony; the strongest carries evidence grade D. For example: Paeonol suppresses prostate cancer progression by regulating the miR-145-5p/GOLM1 axis.
How strong is the evidence for Paeony?
The strongest finding for Paeony carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Paeony safe? What are the side effects?
No major safety issues are recorded for Paeony in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Paeony interact with medications?
No drug interactions are recorded for Paeony in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Paeony?
Paeony is also known as: Пион, pivoine.
Is Paeony a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Paeonia lactiflora-derived extracellular vesicles ameliorate diabetic peripheral neuropathy by modulating chemokine-guided immune trafficking in peripheral nerves. literature abstract metadata
- T2 Monoterpenoids from the roots of Paeonia lactiflora Pall. and their neuroprotective activity. literature abstract metadata
- T2 Paeoniflorin elevates the expression of SOCS3 in macrophages to prevent MIA-induced osteoarthritis in mice. literature abstract metadata
- T2 Paeonol inhibits prostate cancer progression via the miR-145-5p/GOLM1 axis. literature abstract metadata
- T2 Evaluation and physiological response of peony (Paeonia lactiflora Pall.) under salt stress. literature abstract metadata
- T2 A Review of the Pharmacodynamics and Pharmacokinetics of Albiflorin. literature abstract metadata