Sophora alopecuroides
Sophora alopecuroides
Sophora alopecuroides, commonly known as Huangbai or Chinese sophora root, is a traditional medicinal plant used in East Asian herbal practices. It has been traditionally employed for its purported anti-inflammatory and antibacterial properties, though specific uses vary across different traditions without clear documentation. Scientific evidence suggests that compounds from Sophora alopecuroides exhibit significant anti-inflammatory effects by inhibiting the production of nitric oxide (NO), tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6). Additionally, it has shown potential in alleviating lung ischemia-reperfusion injury through modulation of ferroptosis via the STAT-1 pathway. Research also indicates anti-cancer properties, particularly against ovarian cancer by modulating the tricarboxylic acid cycle and glycolysis, as well as counteracting multidrug resistance in breast cancer; however, further investigation is needed to identify specific active components and mechanisms. No major safety concerns have been recorded for Sophora alopecuroides. There are also no reported drug interactions associated with its use.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- ALOperine from Sophora alopecuroides exhibits anti-ovarian cancer effects by modulating the tricarboxylic acid cycle and glycolysis.
- Two new matrine-methyl adducts from Sophora alopecuroides show potent anti-inflammatory properties by inhibiting NO, TNF-α, and IL-6 production and down-regulating iNOS and COX-2.
- Aloperine alleviated lung ischemia-reperfusion injury by modulating ferroptosis via the STAT-1 pathway, but no definitive health advice is provided.
- The chloroform fraction from Sophora alopecuroides exhibited potential in counteracting multidrug resistance in breast cancer, though specific active components and mechanisms require further investigation.
Frequently asked questions
What is Sophora alopecuroides?
Sophora alopecuroides (Sophora alopecuroides) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Sophora alopecuroides?
4 sourced findings are recorded for Sophora alopecuroides; the strongest carries evidence grade D. For example: ALOperine from Sophora alopecuroides exhibits anti-ovarian cancer effects by modulating the tricarboxylic acid cycle and glycolysis.
How strong is the evidence for Sophora alopecuroides?
The strongest finding for Sophora alopecuroides carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Sophora alopecuroides safe? What are the side effects?
No major safety issues are recorded for Sophora alopecuroides in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Sophora alopecuroides interact with medications?
No drug interactions are recorded for Sophora alopecuroides in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Sophora alopecuroides?
Sophora alopecuroides is also known as: Софора лисохвостная.
Is Sophora alopecuroides a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Computational and Experimental Analysis of Sophora alopecuroides L. Chloroform Fraction: Active Components and Anti-Breast Cancer Resistance Mechanisms. literature abstract metadata
- T2 Aloperine exerts anti-ovarian cancer effects by regulating the tricarboxylic acid cycle and glycolysis: A comprehensive study integrating network pharmacology, molecular docking, metabolomics, and experimental validation. literature abstract metadata
- T2 Aloperine alleviates lung ischemia-reperfusion injury by modulating ferroptosis via the STAT-1 pathway. literature abstract metadata
- T2 Two new matrine-methyl adducts from Sophora alopecuriodes with anti-inflammatory activity via ROS/HIF-1α regulation. literature abstract metadata