Shrubby sophora
Sophora flavescens
Sophora flavescens, commonly known as Kushen in traditional Chinese medicine, is traditionally used for treating various conditions such as fever, inflammation, and skin diseases. Scientific evidence suggests that SWHQD (Sophora Flavescens Extract) may suppress colorectal cancer through mechanisms involving NCOA4/FTH1-mediated ferritinophagy-induced ferroptosis. Kushenol E has been shown to mitigate sepsis-associated cognitive dysfunction by inhibiting microglial IDO1 activity, and Matrine can improve myocardial ischemia-reperfusion injury by reducing triglyceride accumulation and promoting CPT1b expression through JAK2-STAT3 activation. SFG (Sophora Flavescens Granules) alleviates DSS-induced ulcerative colitis in mice by restoring the Th17/Treg balance and reshaping the gut microbiome, with mechanisms partly attributed to PI3K/AKT/NF-κB pathway inhibition. No major safety issues or drug interactions have been recorded for Sophora flavescens.
- Best evidence
- D
- Cautions
- —
Informational only. Traditional use does not mean proven effectiveness. Evidence and safety vary — check the cited sources.
What the science says
- SWHQD suppresses colorectal cancer through NCOA4/FTH1-mediated ferritinophagy-induced ferroptosis.
- Kushenol E from Sophora flavescens mitigates sepsis-associated cognitive dysfunction by inhibiting microglial IDO1 activity.
- SFG alleviates DSS-induced ulcerative colitis in mice by suppressing inflammation and restoring tight junction proteins and the gut microbiome.
- Matrine improved myocardial ischemia-reperfusion injury by reducing triglyceride accumulation and promoting CPT1b expression through JAK2-STAT3 activation.
Frequently asked questions
What is Shrubby sophora?
Shrubby sophora (Sophora flavescens) is a plant documented in FolkKB's traditional-medicine reference, drawn from sourced literature and cross-checked against the evidence.
What does the scientific evidence say about Shrubby sophora?
4 sourced findings are recorded for Shrubby sophora; the strongest carries evidence grade D. For example: SWHQD suppresses colorectal cancer through NCOA4/FTH1-mediated ferritinophagy-induced ferroptosis.
How strong is the evidence for Shrubby sophora?
The strongest finding for Shrubby sophora carries evidence grade D — preliminary or traditional. Grades run A (strongest) to D (preliminary or traditional).
Is Shrubby sophora safe? What are the side effects?
No major safety issues are recorded for Shrubby sophora in our sources, but the data may be incomplete. Consult a qualified professional before use.
Does Shrubby sophora interact with medications?
No drug interactions are recorded for Shrubby sophora in our sources. This does not rule them out — check with a pharmacist.
What are the common names of Shrubby sophora?
Shrubby sophora is also known as: Софора желтоватая.
Is Shrubby sophora a proven treatment?
No. FolkKB is informational only. Traditional use and early findings are not proof of efficacy or safety — consult a qualified professional and never self-treat.
Sources
- T2 Kushenol E alleviates sepsis-associated cognitive dysfunction via microglial indoleamine 2,3-dioxygenase 1 inhibition. literature abstract metadata
- T2 Sanwu Huangqin decoction induces ferroptosis in colorectal cancer cells by triggering NCOA4/FTH1-mediated ferritinophagy. literature abstract metadata
- T2 Sophoraflavanone G alleviates ulcerative colitis in mice by reshaping the gut microbiome and restoring the Th17/Treg balance through the PI3K/AKT/NF-κB signaling pathway. literature abstract metadata
- T2 Matrine ameliorated myocardial ischemia-reperfusion injury through lipid accumulation reduction by activating JAK2-STAT3-CPT1 signaling pathway. literature abstract metadata